How Folic Acid interacts with Oral contraceptives

Interaction type: Depletions

Interaction rating: Study Supported

Studies report that oral contraceptives interrupt the breakdown of folic acid and may decrease the amount of folic acid in the body. Supplementation with the affected nutrient may be necessary. (1) (2)

These drugs include norethindrone, ethynodiol diacetate, norgestrel, norgestimate, ethinyl estradiol, drospirenone, desogestrel, levonorgestrel


  1. View Abstract: Webb JL. Nutritional Effects of Oral Contraceptive Use: A Review. J Reprod Med. Oct1980;25(4):150-56.
  2. View Abstract: Shojania AM. Oral Contraceptives: Effect of Folate and Vitamin B12 Metabolism. Can Med Assoc J. Feb1982;126(3):244-7.