How Folic Acid interacts with metformin

Interaction type: Depletions

Interaction rating: Study Supported

Metformin may decrease the amount of folic acid in the body. Supplementation with the affected nutrient may be necessary. (1)


  1. View Abstract: Carlsen, SM, et al. Metformin Increases Total Serum Homocysteine Levels in Non-diabetic Male Patients with Coronary Heart Disease. Scand J Clin Lab Invest. Oct1997;57(6):521-27.