How Folic Acid interacts with methotrexate

Interaction type: Depletions

Interaction rating: Study Supported

Studies have shown that methotrexate can decrease the amount of folic acid in the body. Supplementation with the affected nutrient may be necessary. (1) (2)

References

  1. View Abstract: Dijkmans BA. Folate Supplementation and Methotrexate. Br J Rheumatol. Dec1995;34(12):1172-74.
  2. View Abstract: Leeb BF, Witzmann G, Ogris E, et al. Folic Acid and Cyanocobalamin Levels in Serum and Erythrocytes During Low-dose Methotrexate Therapy of Rheumatoid Arthritis and Psoriatic Arthritis Patients. Clin Exp Rheumatol. Jul-Aug1995;13(4):459-63.