How Folic Acid interacts with methotrexate

Interaction type: Depletions

Interaction rating: Study Supported

Studies have shown that methotrexate can decrease the amount of folic acid in the body. Supplementation with the affected nutrient may be necessary. (1) (2)


  1. View Abstract: Dijkmans BA. Folate Supplementation and Methotrexate. Br J Rheumatol. Dec1995;34(12):1172-74.
  2. View Abstract: Leeb BF, Witzmann G, Ogris E, et al. Folic Acid and Cyanocobalamin Levels in Serum and Erythrocytes During Low-dose Methotrexate Therapy of Rheumatoid Arthritis and Psoriatic Arthritis Patients. Clin Exp Rheumatol. Jul-Aug1995;13(4):459-63.