How Folic Acid interacts with Potassium-sparing diuretics

Interaction type: Interactions

Interaction rating: Case Study Support

An animal study noted that triamterene inhibits the absorption of folic acid in the intestines. Supplementation with the affected nutrient may be necessary. (1) (2)

These drugs include amiloride, triamterene, spironolactone


  1. View Abstract: Lambie DG, et al. Drugs and Folate Metabolism. Drugs. Aug1985;30(2):145-55.
  2. Lieberman FL, Bateman JR. Megaloblastic Anemia Possibly Induced by Triamterene in Patients with Alcoholic Cirrhosis. Two Case Reports. Ann Intern Med. Jan1968;68(1):168-73.