How Folic Acid interacts with sulfasalazine

Interaction type: Depletions

Interaction rating: Study Supported

Animal studies have shown that this medication interrupts the use of folic acid in the body. Supplementation with the affected nutrient may be necessary. (1)


  1. View Abstract: Baggott JE, et al. Inhibition of Folate-dependent Enzymes by Nonsteroidal Anti-Inflammatory Drugs. Biochem J. 1992;282(Pt 1):197-202.