How Eicosapentaenoic Acid (EPA) interacts with orlistat

Interaction type: Interactions

Interaction rating: Potential/Theoritical

This medication decreases the absorption of fat-soluble nutrients, such as EPA, from the digestive tract. It is recommended not to take these agents at the same time. Supplementation with the affected nutrient may be necessary. (1) (2)


  1. View Abstract: Heck AM, Yanovski JA, Calis KA. Orlistat, A New Lipase Inhibitor for the Management of Obesity. Pharmacotherapy. Mar2000;20(3):270-9.
  2. Xenical (orlistat), Product Prescribing Information. Roche Laboratories, Inc. Nutley, New Jersey. Sep2000.