How Biotin interacts with Antibiotics

Interaction type: Depletions

Interaction rating: Potential/Theoritical

Some of the common strains of Bifidobacterium that normally colonize the colon are known to synthesize biotin as well as other B-vitamins. Antibiotics may destroy this normal bowel flora which may decrease the production of biotin. Supplementation with the affected nutrient may be necessary. (1)

These drugs include Aminoglycosides, Cephalosporins, Fluoroquinolones, Quinolones, Macrolides, Penicillins, Sulfonamides, Tetracyclines, Trimethoprin-containing antibiotics, Carbapenems, Monobactams, chloramphenicol, spectinomycin, Streptogramins, vancomycin, Oxalodinones, Lincosamides, Nitrofurans


  1. View Abstract: Cummings JH, et al. Role of Intestinal Bacteria in Nutrient Metabolism. JPEN J Parenter Enteral Nutr. Nov1997;21(6):357-65.