How Biotin interacts with Anticonvulsants

Interaction type: Depletions

Interaction rating: Study Supported

Anticonvulsant drugs may exert a dose-dependent lowering of biotin. Supplementation with the affected nutrient may be necessary. (1) (2) (3)

These drugs include phenytoin, carbamazepine, primidone, gabapentin, valproic acid, felbamate, lamotrigine, mephenytoin, fosphenytoin, clonazepam, ethosuximide, diazepam, clorazepate dipotassium, levatiracetam, tiagabine, topiramate, methsuximide, phensuximide, trimethadione, magnesium sulfate, acetazolamide, oxcarbazepine, zonisamide, ethotoin


  1. View Abstract: Krause KH, et al. Biotin Status of Epileptics. Ann N Y Acad Sci. 1985;447:297-313.
  2. View Abstract: Said HM, et al. Biotin Transport in the Human Intestine: Inhibition by Anticonvulsant Drugs. Am J Clin Nutr. Jan1989;49(1):127-31.
  3. View Abstract: Mock DM, et al. Disturbances in Biotin Metabolism in Children Undergoing Long-Term Anticonvulsant Therapy. J Pediatr Gastroenterol Nutr. 1998;26(3):245-50.