How Beta-Carotene interacts with Bile acid sequestrants

Interaction type: Interactions

Interaction rating: Study Supported

Cholestyramine resin reportedly inhibits the absorption of fat-soluble nutrients including vitamin A and beta-carotene. Colestipol, at a dose of 30 gm/day, has been reported to cause a 30% lowering of serum total carotenoid levels. Supplementation with the affected nutrient(s) may be necessary. (1) (2)

These drugs include cholestyramine, colestipol, colesevelam


  1. View Abstract: Knodel LC, Talbert RL. Adverse Effects of Hypolipidaemic Drugs. Med Toxicol. Jan1987;2(1):10-32.
  2. View Abstract: Probstfield JL, et al. Carotenoids and Vitamin A: The Effect of Hypocholesterolemic Agents on Serum Levels. Metabolism. Jan1985;34(1):88-91.