How Beta-Carotene interacts with colchicine

Interaction type: Depletions

Interaction rating: Study Supported

Colchicine has been reported to produce gastrointestinal side effects that may cause increased fecal excretion of fat as well as other nutrients. Since beta-carotene is a fat-soluble nutrient, regular use of colchicine will potentially reduce the absorption of beta-carotene. Supplementation with the affected nutrient may be necessary. (1)


  1. Race TF, et al. Intestinal Malabsorption Induced by Oral Colchicine. Comparison with Neomycin and Cathartic Agents. Am J Med Sci. Jan1970;259(1):32-41.