How Calcium interacts with digoxin

Interaction type: Depletions

Interaction rating: Proven

In an experiment with dogs, it was shown that therapy with digoxin caused an increase in renal excretion of calcium. Supplementation with the affected nutrient may be necessary. (1)


  1. Kupfer S, Kosovsky JD. Effects of cardiac glycosides on renal tubular transport of calcium, magnesium, inorganic phosphate and glucose in the dog. J Clin Investig. 1965;44:1143.