How Calcium interacts with isoniazid

Interaction type: Depletions

Interaction rating: Proven

Isoniazid causes a reduction of both vitamin D and serum calcium levels, which could result in skeletal problems. Supplementation with the affected nutrients may be necessary. (1)


  1. View Abstract: Brodie MJ, et al. Effect of Isoniazid on Vitamin D Metabolism and Hepatic Monooxygenase Activity. Clin Pharmacol Ther. Sep1981;30(3):363-67.