How Calcium interacts with Potassium-sparing diuretics

Interaction type: Depletions

Interaction rating: Proven

It has been reported that these medications can cause increased renal excretion of calcium. Supplementation with the affected nutrient may be necessary. (1)

These drugs include amiloride, triamterene, spironolactone


  1. Hanze S, et al. Studies of the Effect of the Diuretics Furosemide, Ethacrynic Acid and Triamterene on Renal Magnesium and Calcium Excretion. Klin Wochenschr. Mar1967;45(6):313-14.