How Arginine interacts with sildenafil

Interaction type: Interactions

Interaction rating: Potential/Theoritical

Large doses of arginine could potentially magnify the vasodilation activity of Viagra (sildenafil), causing a hypotensive effect. This may alter the effects of this medication and possibly the dose needed for treatment. Use with caution. (1)


  1. View Abstract: Tentolouris C, Tousoulis D, Goumas G, et al. L-Arginine in Coronary Atherosclerosis. Int J Cardiol. Sep2000;75(2-3):123-8.