Wei Ling Xian

Clematidis Radix, Clematis


The decoction is orally taken at a dose of 6-9g, or up to 30g for being choked by fish bone.


Prolonged exposure to protoanemonin can cause skin effervesce and mucosal hyperemia. It is easy for protoanemonin to polymerize into anemonin, which is a toxic component of Wei Ling Xian, and overdose of which can lead to poisoning.

Chemical Composition

Protoanemonin; Saponin; Hederagenin; Epihederagenin; Oleanolic acid; Aglycone; CP0-10, 2a, 3a, 7a, 8a, 9a, 10a, 2b and 3b. (1)


1.Exercise caution when administering this herb to pregnant women and to patients with qi and blood deficiencies.
2.Adhere to recommended safe dosage to prevent herb poisoning.


Anti-tumor effects

The IC50 values of complete clematis saponin (CCS) on the cells of in-vitro cultured Ehrlich ascites carcinoma (EAC), S180 ascites carcinoma (S180A), and hepatic ascites carcinoma (HepA) are 242mg/ml, 193mg/ml and 130mg/ml, respectively. The tumor-weight-inhibiting rates of CCS at 0.25g/kg, 0.5g/kg and 1g/kg on transplanted sarcoma S180 in mice are 40.3%, 55.1% and 53.0%, respectively. These statistics suggest that Wei Ling Xian has anti-tumor effects. CCS (at 0.2g/kg, 0.4g/kg and 0.8g/kg) does not, however, seem to significantly affect mice’s survival time from S180A. (2)


  1. Editorial Committee of Chinese Materia Medica. State Drug Administration of China. Chinese Materia Medica. Shanghai: Science and Technology Press; 1998.
  2. Qiu Guang Qing, et al. Journal of Traditional Chinese Medicinal Material. 1999;22(7):351-353.