Hyperlipidemia and vitamins C&E in children.

Date:

14-Aug-2003

Source

Circulation

Related Monographs

Consumer Data: Vitamin C Vitamin E Hyperlipidemia
Professional Data: Vitamin C Vitamin E Hyperlipidemia

Article

If your health professional says you have hyperlipidemia, this simply means the amount of fat in your blood is higher than it should be. ("Hyper" means high; "lipid" is another word for fat or fat-like substance; "emia" refers to the blood.) Although high cholesterol is the most famous form of hyperlipidemia, blood fats include more than just cholesterol. Triglycerides, phospholipids, and other fatty substances circulate continuously through the bloodstream on their way to and from organs and tissues.

Abnormally high levels of cholesterol in the blood can lead to coronary heart disease and other serious conditions, due to build-up of cholesterol-filled plaque in the arteries. But cholesterol by itself is not the problem. Research has shown that abnormalities in the way cholesterol is transported in the blood are the culprits in setting the stage for arteries to become damaged and clogged with plaque. (This is the condition known as "atherosclerosis.")

A recent study published in the journal Circulation stated that hyperlipidemia is linked to endothelial dysfunction, which can then lead to coronary artery disease (CAD). Antioxidants have illustrated protective effects against CAD. In this particular study, a six-week regimen of vitamin E and vitamin C was administered to hyperlipidemic children. These 15 children took 500 mg of vitamin C and 400 IU of vitamin E daily; in addition children followed a special diet for the next 6 months. Researchers observed the dilation in the brachial artery and found that the vitamin therapy greatly improved the dilation. In conclusion, the authors suggested that, “Antioxidant therapy with vitamins C and E restores endothelial function in hyperlipidemic children.”1

References

1. Engler MM, et al. Antioxidant Vitamins C and E Improve Endothelial Function in Children With Hyperlipidemia. Endothelial Assessment of Risk from Lipids in Youth (EARLY) Trial. Circulation Aug 2003; 10.1161/01.CIR.0000086345.09861.A0)