Melatonin levels may be associated with asthma symptoms.

Date:

23-Sep-2003

Source

Journal of Allergy and Clinical Immunology

Related Monographs

Consumer Data: Asthma Melatonin
Professional Data: Asthma Melatonin

Article

Asthma is a common lung condition in the industrialized world, one that impacts the lives of adults and children alike. Asthma threatens one's essential ability to breathe, to take in oxygen, our most basic and urgent survival need. We cannot live without air for more than a few minutes. Choke off our air supply, and we quickly become frightened and desperate, to the point of panic. It is easy to understand why asthma is one of the most taxing, debilitating health problems a human being can face, both physically and mentally.

When the airways are constricted by an asthma attack, their delicate membrane linings become swollen and inflamed. Almost two-thirds of all people with asthma, about 65 percent, experience their first symptoms—wheezing, shortness of breath, and rapid heartbeat-- by age five. Although asthma is a chronic lung disease that persists for years and even for a lifetime, the bronchial constriction itself is reversible; the attack can be stopped and normal breathing restored.

Recently published in the Journal of Allergy and Clinical Immunology, researchers stated that increased airway inflammation at night added to nocturnal asthma. Therefore, this study examined the influence of melatonin levels in the body and their association with asthma symptoms. Researchers analyzed 24-hour melatonin levels in 3 groups: nocturnal asthma, non-nocturnal asthma, and healthy controls. After the assessment, subjects with nocturnal asthma had elevated levels of melatonin when compared to the healthy controls. The authors concluded by stating, “Nocturnal asthma is associated with elevation and phase delay of peak serum melatonin levels. Elevated melatonin levels might contribute to the pathogenesis of nocturnal asthma.”1

References

1. Sutherland R, et al. Elevated Serum Melatonin is associated with the Nocturnal Worsening of Asthma. J Aller Clin Immuno. Sept 2003;112(3):513-517.