Magnesium and Heart Disease in Men.




Journal of the American College of Nutrition

Related Monographs

Consumer Data: Magnesium
Professional Data: Magnesium


Magnesium is involved in the interaction of more than 300 enzyme reactions in the body. It is necessary for the transmission of nerve impulses, temperature regulation, detoxification, energy production and the formation of healthy bones and teeth. It is also vital for cardiovascular health.

There are many risk factors for heart disease including smoking, obesity, physical inactivity, cholesterol and other lipids, and diabetes. In addition to education on risk factors, there have been many studies on prevention of heart disease through lifestyle changes involving exercise and diet. One such study reviewed the dietary habits of over 60,000 women. This study utilized dietary information from a food frequency questionnaire developed in 1984 that was associated with the Nurses' Health Study. The associations between dietary patterns and CHD risk among 69,017 women aged 38 to 63 years, without history of major chronic diseases were examined and the researchers were able to gather valuable information regarding diet and health factors.

A recent study investigated the role of magnesium in heart disease in men. Data on over 39,000 men was taken from the Health Professionals Follow-Up Study. Dietary information was collected including dietary intake of magnesium, potassium, and zinc. Over a 12-year follow-up period, coronary heart disease was documented in 1,449 men. Of those, 428 were fatal cases. Those who had a higher intake (average of 457 mg per day) had a lower risk of heart disease when compared to those who had a lower intake (average of 269 per day). After adjusting of risks of heart disease such as lifestyle and dietary factors, the researchers found that those who had higher intakes of magnesium had a lower risk of developing coronary heart disease. The authors of this study concluded that, “intake of magnesium may have a modest inverse association with risk of CHD among men.”1


1. Al-Delaimy AK, et al. Magnesium Intake and Risk of Coronary Heart Disease among Men. J Am Coll Nutr. 2004;23(1):63-70.