8-Hydroxytricetin 7-glucuronide, a ?-glucuronidase inhibitor from Scoparia dulcis

Author

Kawasaki, M

Date

1988

Journal

Phytochemistry

Abstract

The 70% EtOH extract of Scoparia dulciis showed inhibitory activity against ?-glucuronidase from bovine liver. Bioassay-directed fractionation of the active extract led to the isolation of three labdane-type diterpene acids, scoparic acid A [1] [6-benzoyl- 12-hydroxy-labda-8(17),13-dien-18-oic acid], scoparic acid B [2] [6-benzoyl-14,15-dinor-13-oxo-8(17)-labden-18-oic acid], and scoparic acid C [3] [6-benzoyl-15-nor-14-oxo-8(17)-labden-18-oic acid], the structures of which were established by spectral means, including X-ray analysis.