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Nigella sativa


Nigella indica Roxb. ex Flem., Nigella truncata Viv

Vernacular Names:

Malaysia Jintan hitam
English Black seed, black cumin, back caraway, nutmeg flower, Roman coriander
French Cumin noir, Nigelle cultivée, Nigelle de Crète
Chinese Zai pei hei zhong cao, Hei xian hao
Hindi Kalonji
Malayalam Karun jiragam, arunjirakam
Arabic Habbah Albarakah

General Information


Nigella sativa is an annual herbaceous plant belonging to the Ranunculacea family, native to southwest Asia. It is especially grown in the East Mediterranen countries for its seeds. It is a bushy, self-branching plant that grows about 20-30 cm tall, with finely divided, linear (but not thread-like) leaves. The flowers are delicate, and usually coloured white or pale to dark blue, with 5-10 petals. The fruit is a large and inflated capsule composed of 3-7 united follicles, each containing numerous seeds.

Plant Part Used:


Chemical Constituents:

N. sativa seeds are a good source of oil and protein. Proximate analysis of the seeds showed a composition of 20.85% protein, 38.20% fat, 4.64% moisture, 4.37% ash, 7.94% crude fibre and 31.94% total carbohydrate (1).  No trace of lead, cadmium and arsenic were found in the seeds.  The predominant elements present were potassium, phosphorus, sodium and iron while zinc, calcium, magnesium, manganese and copper were found at lower levels (1).  The seeds may potentially be an important nutritional source as the content of essential amino acids contributes to about 30% of the total protein content while about 84% of the fatty acids is composed of unsaturated fatty acids, predominantly linoleic and oleic acids (1), (2).

Oil extracts of the seeds also contain significant amounts of sterols. β-Sitosterol was the dominant sterol (69%); while campesterol and stigmasterol constitute 12% and 19%, respectively of the total sterols (2).  The seed oil was found to be rich in polyphenols (1,744 µg/g) and tocopherols (340 µg/g of total a-,b- and g-isomers) (2) .

N. sativa seeds contain 36%-38% fixed oils, proteins, alkaloids, saponins and 0.4%-2.5% essential oil (3). The fixed oil is composed mainly of fatty acids, namely, linoleic (C18:2), oleic (C18:1) and palmitic acids (C16:0) (1), (4), (5), (6), (7).  Many components were characterized from the essential oil, but the major ones were thymoquinone (27.8%-57.0%), ρ-cymene (7.1%-15.5%), carvacrol (5.8%-11.6%), t-anethole (0.25%-2.3%), 4-terpineol (2.0%-6.6%) and longifoline (1.0%-8.0%) (3), (8). Thymoquinone is the main active constituent of the volatile oil extracted from N. sativa (3), (9), (10). Good quality control methods were used for quantifying the pharmacological actives thymoquinone, dithymoquinone, thymohydroquinone and thymol, in both the seed oils and extracts of N.sativa (11).

Other active principles were nigellone, which was isolated from the volatile oil fraction and was found useful in the treatment of bronchial athma (12), and nigellidine which contains an indazole nucleus (13). Three flavonoid glycosides and triterpene saponins were also identified from N. sativa (14), (15).

Traditional Use:

The seeds, on account of their aromatic nature, are used as a spice in cooking, particularly in Italy, Germany, Southern France and Asia. In folk medicine, it is used by the Egyptian public as a diuretic and carminative, while the expressed oil is used in the treatment of asthma, respiratory oppression and coughs (12).

Pre-Clinical Data


Antimicrobial and antidermatophyte activity

The ethanolic extract of N. sativa was shown to have outstanding in vitro antibacterial activity against methicillin resistant and sensitive strains of Staphylococcus aureus (16). Microgram concentrations of the diethyl ether extract of N. sativa (25-400 μg extract/disc) inhibited growth of Gram-positive bacteria (S. aureus), Gram-negative bacteria (Escheria coli and Pseudomonas aeruginosa) and a pathogenic yeast (Candida albicans) (17). Salmonella thyphimurium was non-sensitive to the range of concentrations of the extract used in the study (25-400 μg/disc). The extract showed antibacterial synergism with streptomycin and gentamycin. In vivo studies showed that the diethyl ether extract successfully eradicated localized infections of S. aureus in mice (17).  N. sativa oil may potentially be useful for inhibition of Listeria monocytogenes in food as it showed strong antibacterial activity against 20 strains of the bacteria with the oil producing inhibition zones that were significantly larger than that of gentamicin (18).

N. sativa elicited antiviral effect against murine cytomegalovirus (MCMV) (19). It was suggested that the effect against MCMV infection may be mediated by an increase in macrophage number and function, and IFN-γ production (19).

N. sativa is a potential source for antidermatophyte drugs. The ether extract of the seed and its active principle, thymoquinone produced minimum inhibitory concentrations (MICs) of 10-40 and 0.125-0.25 mg/ml, respectively against 8 species of dermatophytes (4 species of Trichophyton rubrum, 1 specie each of T. interdigitale, T. mentagrophytes, Epidermophyton floccosum and Microsporum canis).  In contrast, the MICs for griseofulvin ranged from 0.00095 to 0.0155 mg/ml (20). This supports its use in folk medicine for the treatment of fungal skin infections (20).  N. sativa extract and thymoquinone showed protection against chromosomal aberrations in mouse cells infected with schistosomiasis (21).  In Schistosomiasis mansoni infected mice, N. sativa oil (2.5 and 5 mL/kg, orally for 2 weeks) either given alone or with praziquantel was able to reduce the number of worms in the liver and the total number of ova deposited in the liver and intestine (22).  There was also an increase in the number of dead ova and a reduction in the granuloma diameters and partial protection against S. mansoni–induced increases in serum activities of L-alanine aminotransferease (ALT), g-glutamyl transferase (GGT) and alkaline phosphatase (AP) and S. mansoni–induced decrease in serum albumin (22)N. sativa crushed seeds showed strong biocidal effects against all stages of S. mansoni namely, the miracidia, cercaria and adult worms and also inhibited egg-laying of adult female worms (23).  These effects were probably mediated by the crushed seeds inducing a state of oxidative stress in the worms (23) and/or through modulation of the immune response as was observed in S. mansoni infected mice (24).

Antioxidant activity

The antioxidant activity of  N. sativa oil extracted using supercritical CO2 as the solvent was dependent on thymoquinone and carvacrol but was only 0.14 of the activity of a-tocopherol (25). The antioxidant potency of a methanolic extract of N. sativa was found to be higher than the aqueous extract in soybean lipoxygenase and rat liver microsomal lipid peroxidation assays, and also in the DPPH assay (26).  The phenolic content in both the methanolic and aqueous extracts was about 4.1 mg/g (26).  Antioxidants present in N. sativa seeds include selenium, DL-a- and DL-g-tocopherol, all-trans retinol, thymoquinone and thymol with mean concentrations of 0.17, 9.02, 5.42, 0.27, 2224.5 and 169.4 mg/kg fresh weight, respectively (27).  N. sativa and thymoquinone partly protected rat gastric mucosa from acute ethanol-induced gastric mucosal damage, with the gastroprotection mediated by their antiperoxidative, antioxidant and antihistaminic effects (28).  Supplementation of the diet of rats fed oxidised corn oil with N. sativa led to an improvement in the overall antioxidant capacity as evidenced by a marked reduction in red blood cell hemolysis and plasma AST/ALT activities and a reduction in the formation of thiobarbituric acid reactive substances, indices of peroxiddative damage (29). The antioxidant effects are attributed to thymoquinone, a main constituent of the volatile oil of N. sativa (30). Thymoquinone inhibited iron-dependent microsomal lipid peroxidation with an IC50 of 16.8 µM and is a potent superoxide anion scavenger with IC50of 3.35 µM but did not cause DNA damage in the bleomycin Fe(III) system (30). Rats pretreated with thymoquinone (100 mg/kg orally) or commercial bloack seed oil (100 µL/kg orally) for 30 min and for 1 week were protected against methionine induced-hyperhomocysteinemia and its associated state of oxidative stress when measured at 5 hours after the methionine load (31).

Hepatoprotective activity

The hepatoprotective activity of thymoquinone was compared to silybin, a known hepatoprotective agent (9). Although thymoquinone protected against liver enzymes leakage, the degree of protection was less than that of by silybin.

Analgesic and antiinflammatory activity

The aqueous and methanolic extracts of N. sativa (dose equivalent to 1.25 g dried plant/kg weight) showed analgesic effect in mice as it produced significant increases in reaction times in the hot plate and pressure tests (32), (33). Both extracts elicited depressant activity on exploratory conduct and reduced spontaneous motility in mice without causing failure of motor coordination (33).  Both extracts also reduced the normal body temperature (33).

The aqueous extract also has an anti-inflammatory effect as demonstrated by its inhibitory effects on carrageenan-induced paw edema in mice (32). In rat models of acute lung injury or acute respiratory distress syndrome, thymoquinone (6 mg/kg, administered intraperitoneally) was able to improve lung oxygenation while its co-administration with steroids (thymoquinone 6 mg/kg plus methylprednisolone 10 mg/kg, intraperitoneally) protected lung tissue from the hazardous effects of intratracheal instillation of human gastric juice (pH 1.2) (34). The anti-inflammatory effects of thymoquinone was supported by its ability to attenuate allergic airway inflammation by inhibiting Th2 cytokines and eosinophil infiltration into the airways and goblet cell hyperplasia (10), (35).  Attenuation of airway inflammation occurred concomitant to inhibition of COX-2 (cyclogenase) protein expression and prostaglandin D2 production in a mouse model of allergic airway inflammation induced with ovalbumin (35).

Aqueous and macerated extracts of N. sativa produced relaxant, anticholinergic (functional antagonism) and antihistaminic effects on guinea pig tracheal chains (36).  The relaxant effect of the extracts, however, was probably not associated with the calcium channel blocking effect of the herb as the extracts did not inhibit KCl-induced contraction of tracheal chains (36).

Antitumour activity

The biological activities of N. sativa seeds were recently reviewed (37).  Besides the activities mentioned above, the oil and seed constituents of N. sativa showed antitumour effects in vitro and in vivo (37), (38). N. sativa (50 and 100 mg/kg body weight, orally) given prophylactically to potassium bromate-treated rats elicited potent chemopreventive effects as evidenced by the suppression of hyperproliferative response, renal oxidative stress and toxicity (39)N. sativa also protected against ferric nitrilotriacetate (Fe-NTA)-induced oxidative stress, hyperproliferative response and renal carcinogenesis in rats (40).  The active principle of N. sativa seeds exhibited 50% cytotoxicity to Ehrlich ascites carcinoma, Dalton’s lymphoma ascites and Sarcoma-180 cells at concentrations of 1.5, 3 and 1.5 μg/mL, respectively, with little activity against lymphocytes (41). The ethyl acetate fraction of N. sativa seed showed cytotoxicity against cancer cell lines, viz, P388, Molt4, Wehi 164, LL/2, Hep G2, SW620 and J82 as measured by the 3-(4,5-dimethylthiazol-2-yl)-2,5-phenyltetrazolium bromide (MTT) assay (42).  The anti-tumor effects of N. sativa oil was attributed to the volatile oil obtained from the seed, the major active components of which were thymoquinone and dithymoquinone (43), (42).  Thymoquinone killed cancer cells by a process that involved apoptosis and cell cycle arrest with little effect in non-cancerous cells (44).

Diethylnitrosamine-induced hepatocarcinogenesis was instituted in rats. Ten weeks of feeding of these rats with a decoction made of N. sativa seeds, Smilax glabra rhizome and Hemidesmus indicus root bark (at doses of 4 or 6 g/kg body weight/day, orally) resulted their protection as evidenced by inhibition in the early phase of the carcinogenesis (45), (46).

N. sativa decreased the frequency of mammary carcinoma in rats.  This was associated with decreased levels of markers of tumorigenicity, endocrine derangement oxidative stress and increased apoptotic activity (47).

Anticonvulsant activity

Thymoquinone may have anticonvulsant activity in petit mal epilepsy probably through an opoid receptor-mediated increase in GABAergic tone (48).  The use of N. sativa oil could be a potential approach for arresting or inhibiting seizure genesis caused by excitotoxic agents (49).

Immunomodulatory activity

N. sativa does not seem to have immunomodulatory effect on T-helper 1 and T-helper 2 cells in response to allergen stimulation (50). However, the extract inhibited human neutrophil elastase activity which was mainly attributed to carvacrol (51).

Hematological activity

A methanolic extract of N. sativa showed inhibitory effects on arachidonic acid-induced platelet aggregation and on blood coagulation (52).  The extracts appear to induce transient changes in the coagulation activity of rats (53).  Nigella sativa may have a beneficial role as a hypoglycaemic agent with protective effects against pancreatic β-cell damage from alloxan-induced diabetes in rats by virtue of its ability to decrease oxidative stress and to preserve pancreatic β-cell integrity (54).  The treatment of alloxan-induced diabetic rabbits with N. sativa resulted in lowering of elevated glucose concentrations, and an increase in the lowered serum triiodothyronine concentration (55).  Nigella sativa also increased the depressed red and white blood cells count, the packed cell volume and neutrophil percentage but decreased the elevated heart rate in the alloxan-induced diabetic rabbits (56).

N. sativa oil may also play a role in modulating the balance of fibrinolysis/thrombus formation by modulating the fibrinolytic potential of endothelial cells (57), (58).

Gastric secretion activity

N. sativa extract was proven to have a protective action against ethanol- induced ulcer in rats (59).

Antidiabetes activity


A study used short-circuit technique and was reported to show a dose-dependent glucose tolerance that is as efficient as Metformin drug with ability to reduce weight  of the rats at 2g/kg per day dose (65). A combination of N.sativa and human parathyroid hormone consumed by rats with diabetis for 4 weeks reported to have significant insulin-immunoreactivity decreasing the glucose availability (66).

Antiasthmatic activity


Boiled extracts of N.sativa when compared with theophylline at respective doses using pulmonary function tests reported significant improvement in the expiratory flow which is comparable to theophylline and salbutamol during onset treatment only (67).


Pulmonary protective activity

A study reported that rats with lung injury due to foreign materials into the  trachea and lungs was treated with N.sativa for 7 days and significant results was shown relating to pulmonary investigations such as decrease in peribronchial inflammatory cell infiltration (68).


The fixed oil of N. sativa seeds has low toxicity in mice and rats (60).  This suggests that therapeutic doses of the fixed oil of N. sativa has a wide margin of safety, however, this does not take into account the changes in haemoglobin metabolism and the fall of leucocytes and platelet counts (60).

The acute toxicity of thymoquinone is very low (LD50: 2.4 g/kg with 95% C.L. (1.52–3.77)) in mice (61). The maximum non-fatal dose was 500 mg/kg which is approximately 12 times the anticonvulsive dose of 40 mg/kg.  It is generally well tolerated when given subchronically in drinking water at doses of 30, 60, and 90 mg/kg/day. Hypoglycemia was the only effect associated with the subchronic administration of thymoquinone (61).

The toxicity of N. sativa fixed oil extract is as follows: LD1=0.057 mL/kg, LD10=0.157 mL/kg, LD50=0.542 mL/kg, LD90=1.866 mL/kg, LD99=5.111 mL/kg (62).
In addition, when N.sativa is administered with gentamicin sulphate, the anti-bacterial toxicity is reduced significantly when tested by the creatinine and ural levels as well as increased in superoxide dismutase making N.sativa a good chemical agent of free radicals (69).

Clinical Data

Clinical Trials

No documentation

Adverse EffecTs in Human:

No documentation

Use in Certain Conditions:

Pregnancy / Breastfeeding

No documentation

Age Limitations

No documentation

Chronic Disease Conditions

A study conducted on rats which consumed N.sativa for two months period reported to have thickening of the heart muscle, increased heart rate and tension of heart muscle. Due to this, it is recommended that patients with heart condition should take precaution (70).


Interactions with Drugs:

No documentation

Interactions with Other Herbs / Herbal Constituents:

No documentation



No documentation

Case Reports:

Steinmann et al. (1997) reported a case of a 28-year-old man with a 2-day history of maculopapular eczema who had used pure oil of black cumin topically (63).

Allergic contact dermatitis was reported in a 31 year old woman who used an ointment containing essential oils extracted from the seeds of black cumin (64).

Read More

  1) Botanical Info

  2) Essential Oil


  1. Al-Jassir MS. Chemical composition and microflora of black cumin (Nigella sativa L.) seeds growing in Saudi Arabia. 1992; 45: 239-242
  2. Nergiz C and Otles S. Chemical composition of Nigella sativa L. 1993; 48: 259-261
  3. Hosseinzadeh H and Parvardeh S. Anticonvulsant effects of thymoquinone, the major constituent of Nigella sativa seeds, in mice. 2004; 11: 56-64
  4. Atta MB. Some characteristics of nigella (Nigella sativa L.) seed cultivated in Egypt and its lipid profile. 2003; 83: 63-68
  5. Menounos P, Staphylakis K, Gegiou D. The sterols of Nigella sativa seed oil. 1986; 25: 761-763
  6. Cheikh-Rouhou S, Bedbes S, Hentati B, Blecker C, Deroanne C, Attia H. Nigella sativa L. Chemical composition and physicochemical characteristics of lipid fraction. Food Chemistry. 2007; 101: 673-681
  7. Ramadan MF, Mörsel J. Analysis of glycolipids from black cumin (Nigella sativa L.), coriander (Coriandrum sativum L.) and niger (Guizotia abyssinica Cass.) oilseeds. Food Chemistry. 2003; 80: 197-204
  8. Ghosheh OA, Houdi AA, Crooks PA. High performance liquid chromatography analysis of the pharmacologically active quinones and related compounds in the oil of the black seed (Nigella sativa L.). Journal of Pharmaceutical and Biomedical Analysis. 1999; 19: 757-762
  9. El Gazzar ME, Mezayen RE, Marecki JC, Nicolls MR, Canastar A, Dreskin SC. Anti-inflammatory effect of thymoquinone in a mouse model of allergic lung inflammation. International Immunopharmacology. Journal of Pharmaceutical and Biomedical Analysis. 2006; 6: 1135-1142
  10. D’Antuono LF, Moretti A, Lovato AFS. Seed yield, yield components, oil content and essential oil content and composition of Nigella sativa L. and Nigella damascene L. Industrial Crops and Products. 2002; 15: 59-69
  11. Sayed MD. Traditional medicine in health care. Journal of Ethnoparmacology. 1980; 2: 19-22
  12. Atta-ur-Rahman, Malik S, Hasan SS, Choudhary MI, Ni C, Clardy J. Nigellidine. A new indazole alkaloid from the seeds of Nigella sativa. Tetrahedron Letters. 1995; 36: 1993-1996
  13. Merfort I, Wray V, Barakat HH, Hussein SAM, Nawwar MAM, Willuhn G. Flavonol triglycosides from seeds of Nigella sativa. Phytochemistry. 1997; 46: 359-363
  14. Taskin MK, Caliskan OA, Anil H, Abou-Gazar H, Khan IA, Bedir E. Triterpene saponins from Nigella sativa. Journal of Chemistry. 2005; 29: 561-569
  15. Dadgar T, Asmar M, Saifi A, Mazandarani M, Bayat H, Moradi A, Bazueri M, Ghaemi E. Antibacterial activity of certain Iranian medicinal plants against methicilin-resistant and sensitive Staphylococcus aureus. Asian Journal of Plant Sciences. 2006; 5: 861-866
  16. Hanafy MSM and Hatem ME. Studies on the antimicrobial activity of Nigella sativa seed (black cumin). Journal of Ethnopharmacology. 1991; 34: 275-278
  17. Nair MKM, Vasudevan P, Venkitanarayanan K. Antibacterial effect of black oil on Listeria monocytogenes. Food Control. 2005; 16: 395-398
  18. Salem ML and Hossain MS. Protective effect of black seed oil from Nigella sativa against murine cytomegalovirus infection. International Journal of Immunopharmacology. 2000; 22: 729-740
  19. Aljabre AHM, Randhawa MA, Akhtar N, Alakloby OM, Alqurashi AM, Aldossary A. Antidermatophyte activity of ether extract of Nigella sativa and its active principle, thymoquinone. Journal of Ethnopharmacology. 2005; 101: 116-119
  20. Aboul-Ela EI. Cytogenetic studies on Nigella sativa seeds extracts and thymoquinone on mouse cells infected with schistosomiasis using karyotyping. Mutation Research. 2002; 516: 11-17
  21. Mahmoud MR, El-Abhar HS, Saleh S. The effect of Nigella sativa oil against the liver damage induced by Schistosoma mansoni infection in mice. Journal of Ethnopharmacology. 2002; 79: 1-11
  22. Mohamed AM, Metwally NM, Mahmoud SS. Sativa seeds against Schistosoma mansoni different stages. Journal of Ethnopharmacology. 2005; 100: 205-211
  23. Soliman MFM and El-Shenawy NS. Evaluation of the protective effect of two antioxidative agents in mice experimentally infected with Schistosoma mansoni: Haematological and histopathological aspects. Pakistan Journal of Biological Sciences. 2003; 6: 887-897
  24. Machmudah S, Shiramizu Y, Goto M, Sasaki M, Hirose T. Extraction of Nigella sativa L. using Supercritical CO2: A Study of Antioxidant Activity of the extract. Separation Science and Technology. 2005; 40: 1267-1275
  25. Thippeswamy NB and Naidu KA. Antioxidant potency of cumin varieties – cumin, black cumin and bitter cumin – on antioxidant systems. European Food Res. Technology. 2005; 220: 472-476
  26. Al-Saleh IA, Billedo G, El-Doush II. Levels of selenium, DL-a-tocopherol, DL-¿-tocopherol, all-trans-retinol, thymoquinone and thymol in different brands of Nigella sativa seeds. Journal of Food Composition and Analysis. 2006; 19: 167-175
  27. Kanter M, Coskun O, Uysal H. The antioxidative and antihistaminic effect of Nigella sativa and its major constituent, thymoquinone on ethanol-induced gastric mucosal damage. Arch Toxicol. 2006; 80: 217-224
  28. Al-Othman AM, Ahmad F, Al-Orf S, Al-Murshed KS, Arif Z. Effect of dietary supplementation of Ellataria cardamomun and Nigella sativa on the toxicity of rancid corn oil in rats. Intrnational Journal of Pharmacology. 2006; 2(1): 60-65
  29. Badary OA, Taha RA, El-Din AMG, Abdel-Wahab MH. Thymoquinone is a potent superoxide anion scavenger. Drug and Chemical Toxicology. 2003; 26: 87-98
  30. El-Saleh SC, Al-Sagair OA, Al-Khalaf MI. Thymoquinone and Nigella sativa oil protection against methionine-induced hyperhomocysteinemia in rats. International Journal of Cardiology. 2004; 93: 19-23
  31. Al-Ghamdi MS. The anti-inflammatory, analgesic and antipyretic activity of Nigella sativa. Journal of Ethnopharmacology. 2001; 76: 45-48
  32. Al-Naggar TB, Gómez-Serranillos MP, Carretero ME. Villar AM. Neuropharmacological activity of Nigella sativa L. extracts. Journal of Ethnopharmacology. 2003; 88: 63-68
  33. Isik AF, Kati I, Bayram I, Ozbek H. A new agent for treatment of acute respiratory distress syndrome: thymoquinone. An experimental study in a rat model. European Journal of Cardio-thoracic Surgery. 2005; 28: 301-305
  34. El Mezayen RE, Gazzar EM, Nicolls MR, Marecki JC, Dreskin SC, Nomiyama H. Effect of thymoquinone on cyclooxygenase expression and prostaglandin production in a mouse model of allergic airway inflammation. Immunology Letters. 2006; 106: 72-81
  35. Boskabady MH, Shirmohammadi B, Jandaghi P, Kiani S. Possible mechanism(s) for relaxant effect of aqueous and macerated extracts from Nigella sativa on tracheal chains of guinea pig. BMC Pharmacology. 2004; 4: 1-6
  36. Gilani AH, Jabeen Q, Khan MAU. A review of medicinal uses and pharmacological activities of Nigella sativa. Pakistan. Journal of Biological Sciences. 2004; 4: 441-451
  37. Salem M.L. Immunomodulatory and therapeutic properties of the Nigella sativa L. seed. International Immunopharmacology. 2005; 5: 1749-1770
  38. Suryavanshi VL, Sathe PA, Baing MM, Singh GR, Lakshmi SN. Determination of Rutin in Amaranthus spinosus Linn. Whole Plant Powder by HPTLC. International Immunopharmacology. 2007; 5: 1749-1770
  39. Khan N and Sultana S. Inhibition of two stage renal carcinogenesis, oxidative damage and hyperproliferative response by Nigella sativa. Journal of Cancer Prevention. 2005; 14: 159-168
  40. Salomi NJ, Nair SC, Jayawardhanan KK, Varghese CD and Panikkar KR. Antitumour principles from Nigella sativa seds. Cancer Letters. 1992; 63: 41-46
  41. Swamy SMK and Tan BKH. Cytotoxic and immunopotentiating effects of ethanolic extract of Nigella sativa L. seeds. Journal of Ethnopharmacology. 2000; 70: 1-7
  42. Shoieb AM, Elgayyar M, Dudrick PS, Bell JL, Tithof PK. In vitro inhibition of growth and induction of apoptosis in cancer cell lines by thymoquinone. International Journal of Oncology. 2003; 22: 107-113
  43. Khan N, Sharma S, Sultana S. Nigella sativa (black cumin) ameliorates potassium bromate-induced early events of carcinogenesis: diminution of oxidative stress. Human and Experimental Toxicology. 2003; 22: 193-203
  44. Iddamaldeniya SS, Wickramasinghe SMDN, Thabrew I, Ratnatunge N, Thammitiyagodage MG. Protection against diethylnitrosoamine-induced hepatocarcinogenesis by an indigenous medicine comprised of Nigella sativa, Hemidesmus indicus and Smilax glabra: a preliminary study. Journal of Carcinogenesis. 2003; 22: 2-6
  45. Iddamaldeniya SS, Thabrew MI, Wickramasinghe SMDN, Ratnatunge N, Thammitiyagodage MG. A long-term investigation of the anti-hepatocarcinogenic potential of an indigenous medicine comprised of Nigella sativa, Hemidesmus indicus and Smilax glabra. Journal of Carcinogenesis. 2006; 5: 11
  46. El-Aziz MAA, Hassan HA, Mohamed MH, Meki AMA, Abdel-Ghaffar SKH, Hussein MR. The biochemical and morphological alterations administration of melatonin, retinoic acid mammary carcinoma: an animal model. Int. J. Exp. Path. 2005; 86: 383-396
  47. Hosseinzadeh H, Parvardeh S, Nassiri-Asl M, Mansouri M. Intracerebroventricular administration of thymoquinone, the major constituent of Nigella sativa seeds, suppresses epileptic seizures in rats. Med. Sci. Monit. 2005; 11: 106-110
  48. Ilhan A, Gurel A, Armutcu F, Kamisli S, Iraz M. Antiepileptogenic and antioxidant effects of Nigella sativa oil against pentylenetetrazol-induced kindling in mice. Neuropharmacology. 2005; 49: 456-464
  49. Büyüköztürk S, Gelincik A, Ozseker F, Genç S, Savran FO, Kiran B. Yillar G, Erden S, Aydin F, Colakoglu B, Dal M, Ozer H, Bilir A. Nigella sativa (Black seed) oil does not affect the T-helper 1 and T-helper 2 type cytokine production from splenic mononuclear cells in allergen sensitized mice. Journal of Ethnopharmacology. 2005; 100: 295-298
  50. Kacem R and Meraihi Z. Effects of essential oil extracted from Nigella sativa (L.) seeds and its main components on human neutrophil elastase activity. Journal of Ethnopharmacology. 2006; 126: 301-305
  51. Enomoto S, Asano R, Iwahori Y, Narui T, Okada Y, Singab ANB, Okuyama T. Hematological studies on black cumin oil from the seeds of Nigella sativa L. Journal of Ethnopharmacology. 2001; 24: 307-310
  52. Al-Jishi SA, Hozaifa BA. Effect of Nigella sativa on blood hemostatic function in rats. Journal of Ethnopharmacology. 2003; 85: 7-14
  53. Mansi KMS. Effects of oral administration of water extract of Nigella sativa on serum concentrations of insulin and testoterone in alloxan-induced diabetic rats. Pakistan Journal of Biological Sciences. 2005; 8: 1152-1156
  54. Meral I, Yener Z, Ozbek H, Ustun R. Effects of Nigella sativa L. on serum concentrations of thyroid hormones, thyroid stimulating hormone and glucose in alloxan-induced diabetic rabbits. Irish Veterinary Journal. 2003; 56(9): 462-464
  55. Meral I, Donmez N, Baydaz B, Belge F, Kanter M. Effect of Nigella sativa L. on heart rate and some haematological values of alloxan-induced diabetic rabbit. Scand. J. Lab. Anim. Sci. 2004; 31(1): 49-53
  56. Awad EM. In vitro decreases of the fibrinolytic potential of cultured human fibrosarcoma cell line, HT1080, by Nigella sativa oil. Phytomedicine. 2003; 12: 100-107
  57. Awad EM and Binder BR. In vitro induction of endothelial cell fibrinolytic alterations by Nigella sativa. Phytomedicine. 2005; 12: 194-202
  58. El-Dakhakhny M, Barakat M, El-Halim MA, Aly SM. Effects of Nigella sativa oil on gastric secretion and ethanol induced ulcer in rats. Journal of Ethnopharmacology. 2000; 72: 299-304
  59. Zaoui A, Cherrah Y, Mahassini N, Alaoui K, Amarouch H, Hassar M. Acute and chronic toxicity of Nigella sativa fixed oil. Phytomedicine. 2002; 9: 69-74
  60. Badary OA, Al-Shabanah OA, Nagi MN, Al-Kekairi AM, Al-mazar MMA. Acute and subchronic toxicity of thymoquinone in mice. Drug Development. 1998; 44: 448-467
  61. Ozbek H, Ozturk M, Ozturk A, Ceylan E, Yener Z. Determination of Lethal Doses of Volatile and Fixed Oils of Several Plants. Eastern Journal of Medicine. 2004; 9(1): 4-6
  62. Steinmann A, Schätzle M, Agathos M, Breit R. Allergic contact dermatitis from black cumin (Nigella sativa) oil after topical use. Contact Dermatitis. 1997; 36: 268-269
  63. Zedlitz S, Kaufmann R, Boehncke H. Allergic contact dermatitis from black cumin (Nigella sativa) oil-containing ointment. Contact Dermatitis. 2002; 46: 188
  64. Chandrika UG, Svanberg U, Jansz ER. In vitro accessibility of ß-carotene from cooked Sri Lankan green leafy vegetables and their estimated contribution to vitamin A requirement. Journal of the Science of Food and Agriculture. 2006; 86(1): 54-61(8)
  65.  M. Bouchra, D. Robert, E. A. F. Moulay, E. Bruno, M. Lahcen, B. A. Ali, C. M. Louis, C. Yahia, S. H. Pierre. Nigella sativa inhibits intestinal glucose absorption and improves glucose tolerance in rats. Journal of Ethnopharmacology. 30 January 2009;3(121):419-424
  66.  F. A. Mehmet, K. Mehmet, D. Senayi, E. K. Murat, B. Sadik. Combination therapy of Nigella sativa and human parathyroid hormone on bone mass, biomechanical behavior and structure in streptozotocin-induced diabetic rats. Acta Histochemica. 1 August 2007;4(109):304-314
  67. M.H. Boskabady, N. Mohsenpoor, L. Takaloo. Antiasthmatic effect of Nigella sativa in airways of asthmatic patients. Phytomedicine, In Press, Corrected Proof. [Available online 10 February 2010]
  68. K. Mehmet. Effects of Nigella sativa seed extract on ameliorating lung tissue damage in rats after experimental pulmonary aspirations. Acta Histochemica. September;5(111): 393-403  
  69. M. M. Ahmed, S. Bassem, A. A. E Amany, A. E. Ahmed, A. A. Fahad. Protective Effects of Nigella Sativa Oil on Propoxur-Induced Toxicity and Oxidative Stress in Rat Brain Regions. Pesticide Biochemistry and Physiology, In Press, Accepted Manuscript. [Available online 31 May 2010]
  70. M.N. El-Bahai, M.T. Al-Hariri, T. Yar, A.O. Bamosa. Cardiac inotropic and hypertrophic effects of Nigella sativa supplementation in rats. International Journal of Cardiology. 24 January 2009;3(131):e115-e117
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1.               M. Bouchra, D. Robert, E. A. F. Moulay, E. Bruno, M. Lahcen, B. A. Ali, C. M. Louis, C. Yahia, S. H. Pierre. Nigella sativa inhibits intestinal glucose absorption and improves glucose tolerance in rats. Journal of Ethnopharmacology. 30 January 2009;3(121):419-424 

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