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Coscinium blumeanum

Synonyms

Cocculus blumeanus, Coscinium fenestratum 

Vernacular Names:

Malaysia

Akar Kuning, Mengkunyit, Merkunyit, Sekunyit, Kekunyit  (Malay); Tuba Kupak (Sakai)

Indonesia

Lubu Alang [1] [3]

General Information

Description

Coscinium blumeanum Mires is a member of the Menispermaceae family. It is a woody climber, whitish and wooly. The leaves are coriaceous, oblong-ovate or oblong shortly acuminate with rounded base and peltate. The upper surface is glabrous while the underside is white and tomentose;  measuring 20-30cm x 10-15cm. There are 7 nerves radiating from the apex to the petiole with reticulations very prominent and secondary nerves inarching near the edge. The petiole measures 15-20cm long and thickened at both ends. The male inflorescence from the old wood measures 10-12cm long, wooly-tomentose; branchlets 7.5cm long. The heads globose measure 1cm across. The sepals and petals light yellow in colour, silky-tomentose outside, lanceolate sub-spathulate, inner ones narrower. The stamens are 6 in number. [5]

Plant Part Used

Roots [3]

Chemical Constituents

Palmatine, berberine, jatrorrhizine, columbamine, triacontanyl caffeate [2]

Traditional Used:

Skin Diseases

Pounded roots soaked in water is used to treat cuts and sores in the Malay villages. Lotion made from pounded roots and stem is applied on skin to treat miliaria. [3]

Pre-Clinical Data

Pharmacology

Antioxidant activity

In a study on 3 Minespermacea species collectively called Khaminkhruea in Thailand, Niwat et al. [6] isolated four compounds (berberine, palmatine, jartrorrhizine and triacontanyl caffeate) showing antioxidant activities. Of these compound, triacontanyol caffeate proved to be the main antioxidant followed by jatrorrhizine then palmatine and berberine.

Cytotoxic activity

Niwat et al. [6] also studied the cytotoxic activity of extracts of C. blumeanum Miers against brine shrimp and human cancer cell line MCF-7 (Breast adenocarcinoma). The alkaloids berberine, jatrorrhizine and palmatine showed significant cytotoxic activity against brine shrimp and MCF-7 cells while triacontanyl caffeate was less cytotoxic.

Toxicities

No documentation

Clinical Data

Clinical Trials

No documentation

Adverse Effects in Human:

No documentation

Used in Certain Conditions

Pregnancy / Breastfeeding

No documentation

Age Limitations

Neonates / Adolescents

No documentation

Geriatrics

No documentation

Chronic Disease Conditions

No documentation

Interactions

Interactions with drugs

No documentation

Interactions with Other Herbs / Herbal Constituents

No documentation

Contraindications

Contraindications

No documentation

Case Reports

No documentation

Read More

  1) Malaysian Herbal Plants

References

  1. Friedrich Anton Wilhelm Miquel Flora Indie Batavae C.G. van der Post 1860 Amsterdam pg. 157, 382
  2. R. G. Rodrigo, H.L. Holmes, R.H.F. Manske The Alkaloids: Chemistry and Physiology, Volume 52 Acafemic Press Inc. New York 1954 pg. 86, 93, 95
  3. Muhamad Zakaria and Mustasfa Ali Mohd. Traditional Malay Medicinal Plants Institut Penterjemahan Negara Berhad, Kuala Lumpur 2010 pg. 171
  4. I.H. Burkill A Dictionary of Economic Products of the Malay Peninsula Vol.1 Ministry of Agriculture and Cooperatives, Kuala Lumpur 1966 pg. 678
  5. H.N. Ridley The Flora of the Malay Peninsula Volume 1 L. Reeve & Co. Ltd. London 1922 pg. 106
  6. Niwat Keawpradub, Sukanya Dej-adisai and Supreeya Yuenyongsawad Antioxidant and cytotoxic activities of Thai medicinal plants named Khaminkhruea: Arcangelisia flava, Coscinium blumeanum and Fibraurea tinctoria Songklanakarin J. Sci. Technol., 2005, 27(Suppl. 2) : 455-467

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