image
Conservation

Compilation of herbal plants (description, geographical distribution, taxonomy, line drawings), biodiversity and herbarium.

Read More
image
Research & Publication

Description of herbal and T&CM research, searchable publication and process from medicinal plant discovery to clinical trial in producing a high-quality registered herbal drug.

Read More
 
Traditional & Complementary Medicine (T&CM)

 

Definition and description of therapies, policy, training and education, research in the practise of (T&CM) and integrated medicine system.           

Read More

 

News Update

Announcement & Advertisement

Forthcoming Events

Annual Congress on Traditional Medicine

From Wed, 12. May 2021 Until Thu, 13. May 2021

5th International Conference on Medical and Health Informatics (ICMHI 2021

From Fri, 14. May 2021 Until Sun, 16. May 2021

International Conference on Traditional Medicine and Phytochemistry 2021

From Mon, 12. July 2021 Until Wed, 14. July 2021

Asian Symposium on Medicinal Plants and Spices XVII (2020)

From Tue, 17. August 2021 Until Thu, 19. August 2021

Phyllanthus pulcher

Synonyms

Diasperus pulcher, Epistylium pulchrum, Phyllanthus asteranthos

Vernacular Names:

Malaysia Naga Buana, Saga Buana, Naga Jumat, Kelurut Tanjung, Nohok Penuduk, Kayu Putih, Semilit Patung
Thailand
Waan-thoranee-saan[3]

General Information

Description

Phyllanthus pulcher is a member of the Euphorbiaceae family. It is a shrub which can reach up to 1.5 m high. The leaves are distichous with 15-30 pairs along each branchlets. The stipules are triangular-lanceolate measuring 3-4 x 1.5-2 mm, reddish brown in colour, entire or obscurely serrulate. The petiole measures 0.8-1.5 mm. The leaf blade obliquely oblong to ovate-oblong in shape, measuring 1,.8-2 x 0.8-1.3 cm, membranous, abaxillary grey-green, adaxially green, margins slightly revolute. The lateral veins have 4 -6 pairs, obscure. Inflorescence a bisexual axillary fascicle, usually with several male and one female flower. The flowers has ciliate bracts at the base. The male flowers has delicate pedicels, measure 5-10 mm. The sepals 4, ovate-triangular, measuring 2-3 x 1-2 mm, dark red in colour and margins lacerate. The disk glands 4, square or reniform in shape, measure 0.5-0.7 mm wide, flat and membranous. The stamens 2 while the filaments are short and cornnate. The anthers longitudinally dehiscent. The female flowers had filamentous pedicels measuring 15-23 mm. The sepals 6, ovate-triangular in shape, measuring 3.5-4 x 1.5 mm, margins lacerate, midrib thicker abaxially; disk disk-shaped, fleshy, surrounding ovary at base, apex 6-lobed; ovary subglobose, smooth and 3-celled. The styles 3, spreading, bifid at apex. The fruiting pedicels measure 2.5 cm while the sepals are persistent. The capsules subglobose in shape measure 3mm in diameter, brownish in colour and smooth.[1]

Plant Part Used

Leaves and roots [3]

Chemical Constituents

bis(6-methylheptyl)phthalate, phyllanthal-A and 3,4- dihydroxy-5-methoxy-3’,4’,5’-trihydroxyoxepino-chromene-2-one stigmast-5-en-3-ol-oleate, diisobutyl adipate, β- sitosterol, 7-tridecanone and β-sitosteryl-β-D-glucopyranoside 12(13)-dehydro-3α-acetoxyolean-28-oic acid and lupanol acetate 3α-acetoxy-25- hydroxyolean-12-en-28-oic acid, glochidone and glochidonol [2]

Traditional Used:

Decoction of the plant has multiple medicinal values. It can be used as an eye wash, fomentations for nasal ulcers, abscesses, pruritus, fever and renal problems in children. Decoction of the whole plant can relieve stomachache. Paste of the leaves or sap is applied on aching tooth for relieve. The decoction of the roots is a remedy for hypertension. [3]

Pre-Clinical Data

Pharmacology


Cytotoxic activity

Studies on the cytotoxicity of P. pulcher and found a number of compounds isolated have acitivity against a number of cancer cell lines(  MCF-7 (breast), DU-145 (prostate) and H460 (lung)). In the dichloromethane extracts of the aerial parts he identified the four compounds stigmast-5-en-3-ol-oleate, bis(6-methylheptyl)phthalate, phyllanthal-A, and β-sitosteryl-β-D-glucopyranoside to be active against MCF-7 Cells;  phyllanthal-A is also active against DU-145; 3α- acetoxy-25-hydroxyolean-12-en-28-oic acid (197) which was isolated for the first time in this genus showed cytotoxic activity against MCF-7 and DU-145 cell lines and glochidonol  exhibited potent antitumour activity against all the tested cell lines.[4]
Anti-HIV-1 reverse transcriptase activity

A screening exercise for the activity of Phyllanthus sp. found extract of P. pulcher to have the strongest inhibitiong of HIV-RT at IC50 of 5.9 μg/mL.[5]
Antiangiogenic activity

P. pulcher was one of the plants subjected to an anti-angiogenic activity studies. At a dose of 100 μg/ml it recorded an inhibition of 78.8% against rat aortic vascular growth. However when tested on human umbilical vein endotheliad cells it only decrease the proliferation by 15.5%.[6]

Toxicities

No documentation

Clinical Data

Clinical Trials

No documentation

Adverse Effects in Human:

No documentation

Used in Certain Conditions

Pregnancy / Breastfeeding

No documentation

Age Limitations

Neonates / Adolescents

No documentation

Geriatrics

No documentation

Chronic Disease Conditions

No documentation

Interactions

Interactions with drugs

No documentation

Interactions with Other Herbs / Herbal Constituents

No documentation

Contraindications

Contraindications

No documentation

Case Reports

No documentation

References

    1. Flora of China: Phyllanthus pulcher ( http://www.efloras.org/florataxon.aspx?flora_id=2&taxon_id=242337453) [Accessed 11th November 2010]
    2. Bagalkotkar, Gururaj Isloation and Characetrisation of Compounds from Naga Buana (Phyllanthus pulcher) and Similit Matinggi (Casearia capitellata) and their Cytotoxic effects on Cancer cell lines Masters Thesis, Universiti Putra Malaysia ( http://psasir.upm.edu.my/7188/1/FPSK(P)_2007_2a.pdf) Accessed 11th November 2010
    3. Kamaruddin Mat-Salleh, A. Latiff Tumbuhan Ubatan Malaysia Pusat Perkembangan Penyelidikan Universiti Kebangsaan Malaysia Bangi 2001 pg. 347
    4. Bagalkotkar, Gururaj Isolation and Characterisation of Compounds from ‘Naga Buana’ (Phyllanthus Pulcher) and ‘Similit Matinggi’ (Casearia Capitellata) and Their Cytotoxic Effects on Cancer Cell Lines Masters thesis, Universiti Putra Malaysia. (UNSPECIFIED)
    5. I.M.S. Eldeena, E-M. Seowa, R. Abdullaha and S.F. Sulaimana In vitro antibacterial, antioxidant, total phenolic contents and anti-HIV-1 reverse transcriptase activities of extracts of seven Phyllanthus sp South African Journal of Botany 2010
    6. Ng KW, Salhimi SM, Majid AM, Chan KL Anti-angiogenic and cytotoxicity studies of some medicinal plants. Planta Med. 2010 Jun;76(9):935-40
      Normal 0 false false false EN-US X-NONE X-NONE  

      Malaysia – Naga Buana, Saga Buana, Naga Jumat, Kelurut Tanjung, Nohok Penuduk, Kayu Putih, Semilit Patung.

      Thailand – Waan-thoranee-saan

      Explore Further

      Consumer Data

      Consumer data including medicinal herbs, dietary supplement monographs, health condition monographs and interactions and depletions.                                    

      Read More
      Professional Data

      Professional data organized into medicinal herbs, dietary supplement monographs, health condition monographs, T&CM herbs, formulas, health conditions, interactions and depletions.

      Read More
      International Data

      We offer International linkages to provide extensive content pertaining to many facets of T&CM as well as Integrated Medicine. Please register for access.    

      Read More