Stellaria media
Synonyms
No documentation
Vernacular Name
Common chickweed, chickweed, common starwort. [1],[2],[3]
Description
Stellaria media, or chickweed, is a member of the Caryophyllaceae family and is easily recognizable by its numerous, delicate, star-shaped white flowers and oval leaves.[2] It is an ancient plant, likely pre-neotlithic, and has been used as food and as medicine. It has been consumed in salads, as cooked greens, and has been fed to poultry to increase the output of eggs.[9] Traditionally, S. media has been used to treat a variety of internal and external ailments including inflammatory and cutaneous disorders.
S. media produces branching leafy stems from a thin taproot. Leaves vary in size with the lower leaves being larger (up to 25mm) than the upper leaves. The plant is known for its small, star-shaped, white flowers
Origin / Habitat
S. media is abundant in Europe, has been naturalized in the Americas and is now found throughout the world in what would. While the habitats may vary, it requires nutrient-rich soil in order to thrive.
Chemical Constituents
Flavonoids, Carotenoids, Alkaloids, Fatty Acids (omega-3 and omega-6), Ascorbic acid, Tannins, Nitrates.[3],[4],[5],[6],[7]
Plant Part Used
Medicinal Uses
General
Inflammatory disorders
Rheumatism
Gout
External application for skin ailments
Wound healing[3]
Most Frequently Reported Uses
Inflammatory disorders
Rheumatism
Gout[3]
Dosage
Dosage Range
There is insufficient clinical evidence available to guide the dosage for S. media.
Most Common Dosage
No documentation
Pharmacology
Pre-clinical
There is insufficient scientific evidence concerning the activity of S. media and its constituents available in the medical literature to guide any conclusions concerning therapeutic effectiveness. However, laboratory studies employing in vitro assays for antioxidant activity have shown S. media extract to exhibit strong inhibition of xanthine oxidase; the resulting inhibition of xanthine oxidase produced by S. media extract was higher than the inhibition produced by the reference extract.[8] The antioxidant activity associated with S. media extracts may be beneficial in the treatment of certain disorders, such as rheumatism, gout, and disorders of the central nervous system.[8]
Several additional investigations employing alternate Stellaria species are available; these investigations have employed Stellaria dichotoma or Stellaria aquatica. Enzymatic extracts of Stellaria dichotoma, known in the vernacular as S. media and in Chinese as Yinchaihu, have been shown to possess strong antioxidant activity in 1,1-diphenyl-2-picrylhydrazyl (DPPH), hydroxyl, and alkyl radical scavenging assays.[9],[10] Moreover, the results indicated that enzymatic extracts of S. dichotoma are able to inhibit the radical-associated oxidative damage of DNA as evidenced through measurement of the supercoiled pBR322 plasmid DNA to the open circular form.[10] Thereby, the enzymatic extracts of S. dichotoma were dose-dependently shown to protect against hydroxyl-radical induced DNA damage and may indicate potential for therapeutic effectiveness in disorders where antioxidant therapy has shown promising results.[10] Furthermore, the vasodilatory cyclic peptides dichotomin J and K have been isolated from S. dichotoma and have demonstrated a vasorelaxant effect on rat aorta tissue.[12] Antiallergic effects have been documented following in vivo studies employing the murine model to examine the effect of Stellaria dichotoma root extract on ear passive cutaneous anaphylaxis and in vitro studies showing inhibition of dinitrophenylated bovine serum albumin-induced beta-hexosaminidase release in RBL-2H3 cells previously sensitized with anti-dinitrophenylated IgE.[12] Dichotomoside D, a neolignan glycoside isolated from S. dichotoma, has shown antiallergic activity through its inhibition of beta-hexosaminidase release in RBL-2H3 cells; beta-hexosaminidase serves as a degranulation marker because it is released from immunologically-activated mast cells concomitantly with histamine.[13] Dichotomoside D also inhibited the antigen-induced release of tumor necrosis factor-alpha and interleukin-4 in RBL-2H3 cells; these cytokines have been shown to be mediators in the late-phase effects (e.g. edema and erythema) of a biphasic allergic reaction.[1],[13],[3]
Stellaria aquatica, a species of Stellaria commonly used in Korean salads and known as giant S. media, has exhibited strong anticancer activity in MTT assays assessing extracts for cytotoxicity against human pulmonary and gastric carcinoma cell lines (Calu-6 and SNU-601, respectively).[14]
Clinical
No documentation
Interaction and Depletions
Interaction with other Herbs
No documentation
Interaction with Drugs
-Agents with potential or established nephrotoxicity and/or hepatotoxicity
-Non-steroidal anti-inflammatory agents
-Substances (e.g. medications, herbal supplements, foods) containing nitrates and nitrites
-Antihypertensives
-Phosphodiesterase type 5 inhibitors
-Antiplatelet agents
-Anticoagulant agents
-Additional agents that may increase bleeding
-Antirheumatic agents
-Agents used in the treatment of gout
-Anti-seizure agents
-Ergotamine
-Tissue-type Plasminogen Activator
Precautions and Contraindications
Side effects
S. media supplements are contraindicated in patients with a known allergy or hypersensitivity to members of the Stellaria species.
The allergic reactions (predominantly contact dermatitis) and irritant reactions following exposure to S. media have been documented in the literature and cross-sensitivity to members of the Asteraceae family may exist.[1] A case of erythema multiforme and recurrent erythema multiforme with photoaggravation following patch testing to fresh S. media leaves has been documented in medical literature; thin layer chromatography completed on S. media samples revealed the contact allergens borneol, linalool, 1,8-cineole, menthol and additional terpenes.[16] S. media supplements should be used with caution in atopic patients; as with all allergies, the incidence of allergic reactions is higher in patient populations where asthma or atopy is already present.[1],[17]
Stellaria species supplements appear to be well tolerated when consumed in quantities consistent with a normal diet as there are few reports of toxicity associated with its use.[15] There have been insufficiently documented cases in the medical literature that associate onset of nitrate poisoning and paralysis secondary to consumption of high concentrations of tea made from S. media.[15] Whilst these cases must be considered, it is theorized from the isolated nature of these cases that the herb and/or the tea may have been adulterated with an unknown contaminant.[15]
Pregnancy
Patients planning to become pregnant, who are pregnant or breastfeeding should not use Stellaria species supplements without first consulting their medical practitioner; S. media contains nitrates which have been postulated to produce detrimental effects during human and rodent gestation.[18],[19],[20] Symptoms of nitrate toxicity include headache, syncope, vertigo and cutaneous discoloration that manifests in the fingers or lips.
Age limitation
No documentation
Adverse reaction
No documentation
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References
- Jovanovic M, Poljacki M, Mimica-Dukic N et al. Sesquiterpene lactone mix patch testing supplemented with dandelion extract in patients with allergic contact dermatitis, atopic dermatitis, and non-allergic chronic inflammatory skin diseases. Contact Dermatitis. 2004; 51(3):101-110.
- United States Department of Agriculture: Natural Resources Conservation Service. The PLANTS Database. Available from: http://plants.usda.gov. [Accessed on 17 August 2009]. National Plant Data Center. Baton Rouge, LA 70874-4490 USA.
- Gruenwald J, Brendler T, Jaenicke C, eds. PDR for Herbal Medicines. 2nd ed. Montvale, New Jersey: Medical Economics Company; 2000:180-181.
- Guarrera PM, Forti G, Marignoli S. Ethnobotanical and ethnomedicinal uses of plants in the district of Acquapendente (Latium, Central Italy). J Ethnopharmacol. 2005;96(3):429-444.
- Guil JL, Torija ME, Gimenez JJ, Rodriguez I. Identification of fatty acids in edible wild plants by gas chromatography. J Chromatogr A. 1996;719(1):229-235.
- Guil JL, Rodriguez-Garcia I, Torija E. Nutritional and toxic factors in selected wild edible plants. Plant Foods Hum Nutr. 1997;51(2):99-107.
- Budzianowski J, Pakulski G, Robak J. Studies on the antioxidative activity of some C-glycosylflavones. Pol J Pharmacol Pharm. 1991;43(5):395-401.
- Pieroni A, Janiak V, Durr CM, Ludeke S, Trachsel E, Heinrich M. In vitro antioxidant activity of non-cultivated vegetables of ethnic Albanians in southern Italy. Phytother Res. 2002;16(5):467-473.
- Han J, Cai S, Li J et al. Studies on identification of yinchaihu by UV and IR. Zhongguo Zhong Yao Za Zhi. 1999;24(8):454-509.
- Lim BO, Choi SH, Kim EK et al. Antioxidant activity of enzymatic extracts of Stellaria dichotoma. J Med Food. 2008;11(4):723-732.
- Morita H, Iizuka T, Choo CY, Chan KL, Itokawa H, Takeya K. Dichotomins J and K, vasodilator cyclic peptides from Stellaria dichotoma. J Nat. Prod. 2005;68(11):1686-1688.
- Sun B, Morikawa T, Matsuda H et al. Structures of new beta-carboline-type alkaloids with antiallergic effects from Stellaria dichotoma(1,2). J Nat Prod. 2004;67(9):1464-1469.
- Morikawa T, Sun B, Matsuda H, Wu LJ, Harima S, Yoshikawa M. Bioactive constituents from Chinese natural medicines. XIV. New glycosides of beta-carboline-type alkaloid, neolignan, and phenylpropanoid from Stellaria dichotoma L. var. lanceolata and their antiallergic activities. Chem Pharm Bull (Tokyo). 2004;52(10):1194-1199.
- Chon SU, Heo BG, Park YS, Kim DK, Gorinstein S. Total phenolics level, antioxidant activities and cytotoxicity of young sprouts of some traditional Korean salad plants. Plant Foods Hum Nutr. 2009;64(1):25-31.
- McGuffin M, Hobbs C, Upton R, Goldberg A, Eds. American Herbal Products Association’s Botanical Safety Handbook: Guidelines for safe use and labeling for herbs in commerce. Boca Raton, Florida: CRC Press LLC; 1997.
- Jovanovic M, Mimica-Dukic N, Poljacki M, Boza P. Erythema multiforme due to contact with weeds: A recurrence after patch testing. Contact Dermatitis. 2003;48(1):17-25.
- Paulsen E, Otkjaer A, Andersen KE. Sesquiterpene lactone dermatitis in the young: is atopy a risk factor? Contact Dermatitis. 2008;59(1):1-6.
- Ernst E. Herbal medicinal products during pregnancy? Phytomedicine. 2002;9:352-354.
- Winchester PD, Huskins J, Ying J. Agrichemicals in surface water and birth defects in the United States. Acta Paediatr. 2009;98(4):664-669.
- Egorova VV, Iezuitova NN, Nikitina AA, Starchenkov SV, Timofeeva NM. The effects of nitrates on rats during pregnancy on the development of the digestive system in ontogeny. Fiziol Zh Im I M Sechenova. 1993;79(6):93-101.
