Introduction
Dimethylglycine (DMG) is a substance that is found in the cells of all plants and animals. In the human body, it participates in the formation of important amino acids, vitamins, and neurotransmitters.
While DMG can be found in the outer coating of rice and in all seed products, it is produced naturally in the body.
Dosage Info
Dosage Range
50 to 750mg daily.
Most Common Dosage
125mg, 2 or 3 times daily.
Dosage Forms
Capsules and foil-wrapped sublingual tablets.
Reported Uses
One of the most common uses for DMG is in the treatment of autism. While studies on DMG have been informal, they suggest that the supplement, when taken along with vitamin B6 and magnesium, may dramatically improve speech and other factors in autistic children. (1) , (2) Because DMG is safe and inexpensive, such supplementation has been sanctioned by the Autism Research Institute.
While adequate studies are lacking on the subject, DMG may also suppress seizures in people with epilepsy. (3) Meanwhile, DMG is a popular supplement for athletes as well as the trainers of greyhounds and racehorses. Some non-clinical reports suggest that DMG may enhance muscle energy, decrease factors that contribute to muscle cramping, and improve running speed. (4) There is some controversy in the medical community, however, over the validity of these claims.
Finally, studies suggest that DMG may enhance the immune system, especially in response to bacterial invaders like Salmonella. (5)
Toxicities & Precautions
Introduction
[span class=alert]Be sure to tell your pharmacist, doctor, or other health care providers about any dietary supplements you are taking. There may be a potential for interactions or side effects.[/span]
General
This dietary supplement is considered safe when used in accordance with proper dosing guidelines.
Pregnancy / Breast Feeding
To date, the medical literature has not reported any adverse effects related to fetal development during pregnancy or to infants who are breast-fed. Yet little is known about the use of this dietary supplement while pregnant or breast-feeding. Therefore, it is recommended that you inform your healthcare practitioner of any dietary supplements you are using while pregnant or breast-feeding.
Age Limitations
To date, the medical literature has not reported any adverse effects specifically related to the use of this dietary supplement in children. Since young children may have undiagnosed allergies or medical conditions, this dietary supplement should not be used in children under 10 years of age unless recommended by a physician.
References
- Rimland B. Seizures, Vitamin B6, DMG, and Sudden Speech. Autism Research Review International. 1996;10(2):1.
- Vitamin B6/DMG. Letters to the Editor, Autism Research Interview International. 1994;8(2):6.
- Roach ES, Carlin L. N,N-dimethylglycine for epilepsy. N Engl J Med. 1982;307:1081-82.
- Rodiek A. Feeding For Performance. The Equine Athlete. Jun1992;5(3);11-14.
- View Abstract: Reap EA, Lawson JW. Stimulation of the immune response by dimethylglycine, a nontoxic metabolite. J Lab Clin Med. Apr1990;115(4):481-6.