Qing Wei San

Functions

This formula’s primary function is to clear away the stomach-fire and remove heat from the blood. It is used to treat toothaches due to stomach-fire as well as gingival swelling, ulceration, and bleeding, swelling pain in the lips, tongue and cheeks, halitosis, dry mouth and tongue, and red tongue with yellowish fur.

Dosage Info

One dose of the formula in decoction is to be administered daily at two oral takings. 5:1 concentrated extracts: 9 grams/day.

Ingredients

Precautions

Toxicity: No death was observed in 7 days of perfusion of Qing Wei San decocted along or with other drugs to the stomach of mice at dosage of 30ml/kg, 2 times a day. The maximum tolerance dose in both cases exceeded more than 100 times of human dosage.

Pharmacology

Anti-inflammatory Effect: An intra-abdominal injection of 5% Qing Wei San solution (10ml/kg) administered to rats had a significant inhibiting effect on metatarsus inflammation that was caused by egg white and on granulation tissue inflammation formed by the paper strip method. (1)

Bacteria-inhibiting Effect: In vitro experiments have shown that a Qing Wei San decoction has some, but insignificant inhibiting effects on Staphylococcus aureus and Pseudomonas aeruginosa. (2)

Immunization: Injection of a 5% Qing Wei San solution to each mouse stomach at a dosage of 0.5ml can significantly strengthen the phagocytic function of macrophages in the abdomen and can significantly increased the phagocytic percentage and phagocytic index. (3)

Analgesic Effect: Experiments with the hot plate and body-torsion methods have shown that Qing Wei San decocted alone or among other herbs has significant inhibition effects on pain induced by acetic acid in mice. There was no significant difference in effectiveness between the two methods. (4)

Other Effect: Qing Wei San decocted alone or with other herbs can significantly promote the propelling rate in the small intestine of mice. (5)

Clinical Applications

Treating Periodontitis
60 cases of acute periodontitis were treated with Qing Wei San, which consisted of Huang Lian (Coptis Root), Sheng Ma (Cimicifuga Rhizome), Sheng Di Huang (Rehmannia Root), Mu Dan Pi (Moutan), Huang Qi (Astragalus Root), and Sheng Shi Gao (Gypsum). The results showed that the total effectiveness rate was 95%. (6) 45 cases of periodontitis were treated with modified Qing Wei San that consisted of Sheng Ma (Cimicifuga Rhizome), Mu Dan Pi (Moutan), Dang Gui (Chinese Angelica Root), Huang Lian (Coptis Root), Sheng Di Huang (Rehmannia Root), Lu Feng Fang (wasp’s nest), Sheng Shi Gao (Gypsum), Yuan Shen (Scrophularia Root), and Gu Sui Bu (Drynaria Rhizome). Long Dan Cao (Gentian Root), and Chuan Xiong (Cnidium) were added for upper periodontitis. Zhi Zi (Gardenia), Huang Qi (Scutellaria Root), and Bai Shao (White Peony Root) were added for lower periodontitis. Chinese Zao Jiao Ci (Honeylocust Spine) and Shan Ci Gu (Pleione Rhizome) were added for treating suppuration. The results showed that 23 cases were resolved, 17 cases improved, and 5 cases did not respond to the treatment. The total effectiveness rate was 88.9%. (7)

Treating toothache and swollen cheeks
60 cases of toothache and swollen cheeks were treated with modified Qing Wei San. This formula contained Sheng Ma (Cimicifuga Rhizome), Da Huang (Rhubarb), Huang Lian (Coptis Root), Dang Gui (Chinese Angelica Root), Mu Dan Pi (Moutan), Sheng Shi Gao (Gypsum), Jing Jie (Schizonepeta), Fang Feng (Ledebouriella Root), Bai Zhi (Angelica), and Sheng Di Huang (Rehmannia Root). Of the 60 cases treated, after 3 doses, the toothaches stopped and swelling was eliminated in 48 cases. 10 cases reached these results after 6 doses. 2 cases had recovered with more than 6 doses. (8)

Treating diabetes of the type of body fluid impairment and dry heat
A combination of Chinese and Western medicine was used to treat 40 cases of diabetes due to body fluid impairment and dry heat. In both the comparison group and the treatment group (40 cases in each), Phenformin tablets were taken orally 50 mg, 3 times a day. In addition, the treatment group took Di Huang Yin Zi and modified Qing Wei San. The modified Qing Wei San consisted of Sheng Di Huang (Rehmannia Root), Shou Di Huang (Prepared Rehmannia Root), Mai Dong (Ophiopogon Root), Shi Hu (Dendrobium Stem), Tai Zi Shen (Pseudostellaria Root), Huang Qi (Astragalus Root), Di Gu Pi (Wolfberry Bark), Zhi Mu (Anemarrhena Rhizome), Yin Chai Hu (Stellaria Root), Hu Huang Lian (Picrorhiza Rhizome), and Tian Hua Fen (Trichosanthes Root). The ingredients were modified according to the individuals’ symptoms. Five weeks constituted one course of treatment. After 2 courses, the results for the treatment and comparison groups were, respectively: significantly improved in 28 and 9 cases, improved in 6 and 15 cases, and no improvement in 6 and 16 cases. The total effectiveness rates were 85% and 60% (P

References

  1. Li Cheng Lin, et al. Pharmacology research of Qin Wei San. China Journal of Stomatology. 1986;21(1):44-46.
  2. Li Cheng Lin, et al. Pharmacology research of Qin Wei San. China Journal of Stomatology. 1986;21(1):44-46.
  3. Li Cheng Lin, et al. Pharmacology research of Qin Wei San. China Journal of Stomatology. 1986;21(1):44-46.
  4. Cui Jin Chao, et al. Comparison between pharmacology of singly decocted and jointly decocted Qin Wei San. China Journal of Medicine and Drug. 1998;13(2):26-29.
  5. Cui Jin Chao, et al. Comparison between pharmacology of singly decocted and jointly decocted Qin Wei San. China Journal of Medicine and Drug. 1998;13(2):26-29.
  6. Zhu Pin Zhuo. Therapeutic observations of treating acute periodontitis with Qin Wei San. Shanghai Journal of Traditional Chinese Medicine and Herbs. 2000;34(7):37-38.
  7. Wu Shao Yun. Treating 45 cases of periodontitis with modified Qin Wei San. Fujian Journal of Chinese Medicine. 1996;27(6):49.
  8. Zhou Xu. Treating toothache and swelling cheeks with modified Qin Wei San. Journal of Traditional Chinese Medicine Study. 1999;15(6):48.