Qing Wen Bai Du Yin

Functions

This formula’s role is to clear away heat and toxic materials, remove heat from the blood, and purge intense heat. The decoction is used to treat toxic heat of pestilence and intense heat in both qi and blood systems.

Dosage Info

Decoction: One dose is decocted, divided into 2 to 3 portions and administered orally. Sheng Shi Gao (Gypsum) should be decocted first. Powder of buffalo born (Cornu Bubali) should be added to the decoction and evenly mixed.

Ingredients

Precautions

Patients suffering from insufficiency of yang or deficiency of the spleen and stomach should not take the decoction.

Pharmacology

Antipyretic effect: Qing Wen Bai Du Yin had significant fever reducing effects on rabbits with intense heat in both qi and blood systems caused by the endotoxin Bacillus coli and reduced the average fever curve, average highest temperature, and body temperature reaction index. (1) Qing Wen Bai Du Yin administered orally or rectally had a significant antipyretic effect. (2) It is reported that rectal administration was superior to oral administration in having an antipyretic effect. (3)

Antagonizing effect on platelet aggregation: Qing Wen Bai Du Yin had some antagonizing effects on platelet aggregation caused by endotoxins. (4)

Reducing Blood Viscosity: This formula had similar effects to depolymerization, in reducing blood viscosity and diluting the blood (removing heat from the blood and removing blood stasis). It can antagonize hyperviscosity syndrome caused by endotoxins in rabbits. (5)

Influence on T-lymphocyte sub-population: After 15 days of treatment, Qing Wen Bai Du Yin could recover nearly all the abnormal T-lymphocyte sub-population in peripheral blood. (6)

Clinical Applications

Treating child infectious mononucleosis
In the therapeutic principle of clearing away heat to remove toxins and promoting blood circulation to remove blood stasis, modified Qing Wen Bai Du Yin was used to treat 30 cases of child infectious mononucleosis. The decoction consisted of Shi Gao (Gypsum), Zhi Mu (Anemarrhena), Huang Lian (Coptis), Huang Qin (Scutellaria), Zhi Zi (Gardenia), Gan Cao (Licorice), powder of buffalo born (Cornu Bubali), Sheng Di Huang (Rehmannia Root), Chi Shao (Peony Red), Mu Dan Pi (Moutan Bark), Xuan Shen (Scrophularia), and Lian Qiao (Forsythia). The total effectiveness rate was 97%. (7)

Treating multiple drug-tolerant typhoid
Chloramphenicol, sulfamethoxazole, aminobenzylpenicillin, and other antibiotics were used to treat 22 cases in the treatment group and 20 cases in the control group when no positive effects were seen in the patients after 10 days of previous treatment. Qing Wen Bai Du Yin [consisting of Sheng Shi Gao (Gypsum), Sheng Di Huang (Rehmannia Root), Chi Shao (Peony Red), Huang Lian (Coptis), Zhi Zi (Gardenia), Jie Gen (Platycodon Root), Huang Qin (Scutellaria), Zhi Mu (Anemarrhena), Lian Qiao (Forsythia), Xian Zhu Ye (ophatherum), Xuan Shen (Scrophularia), Mu Dan Pi (Moutan), and Gan Cao (Licorice)] was modified and additionally used in the treatment group. The decoction was taken orally once a day for 3 days after the body temperature had returned to normal. The patients in the control group orally took norfloxacin capsules 400 mg 3 times a day, for 14 days, which comprised one course of treatment. The results showed that all patients in treatment group fully recovered. In the control group, 15 cases recovered, 2 cases showed significant improvement, 2 cases had somewhat improved, and 1 case had not improved. (8)

Treating epidemic hemorrhagic fever
The modified Qing Wen Bai Du Yin formula consisted of Sheng Shi Gao (Gypsum), Sheng Di Huang (Rehmannia Root), powder of buffalo born (Cornu Bubali), Zhi Zi (Gardenia), Jie Gen (Platycodon Root), Huang Qin (Scutellaria), Chi Shao (Peony Red), Lian Qiao (Forsythia), Mu Dan Pi (Moutan), Huang Lian (Coptis), Zhi Mu (Anemarrhena), and Xuan Shen (Scrophularia). The decoction was taken orally taken twice a day with an interval of 4 to 6 hours between the administrations. The results showed 21 cases had significant improvement, 10 cases had some improvement, 1 case had no progress, and the total effectiveness rate was 95.3%. (9)

Treating severe allergic skin rash caused by aminobenzylpenicillin
Wang Xichu and others used modified Qing Wen Bai Du Yin to treat severe allergic skin rashes caused by aminobenzylpenicillin. The formula consisted of Sheng Shi Gao (Gypsum) (decocted first), Jin Yin Hua (Lonicera Flower), Sheng Di Huang (Rehmannia Root), Huang Lian (Coptis), Zhi Zi (Gardenia), Huang Qin (Scutellaria), Zhi Mu (Anemarrhena), Chi Shao (Peony Red), Lian Qiao (Forsythia), Mu Dan Pi (Moutan Bark), Zhu Ye (Lophatherum), Chan Yi (Cicada), Bai Xian Pi (Dittany Bark), and Gan Cao (Licorice). The decoction was taken orally once a day for 2 to 4 days. All cases fully recovered. (10)

Treating acute psoriasis of erythroderma type
Qing Wen Bai Du Yin and Western drugs were jointly used to treat 11 cases of acute psoriasis of the erythroderma type. The results were, 7 cases fully recovered (63.6%), 2 cases showed significant progress (18.2%), and 2 cases improved (18.2%). The total effectiveness rate was 100%. (11)

References

  1. Xie Kuo, et al. Qing Wen Bai Du Ying’s therapeutic effect and mechanism on rabbit’s intense heat in both qi and blood systems resulting from endotoxin of Bacillus coli. China Journal of Integrated Medicine. 1993;13(2):94-97,69.
  2. Deng Jing Zhen, et al. Preparation and pharmacological effects of rectal administration of Qing Weng Bai Du San. Journal of Traditional Chinese Medicine Information. 1986;(3):28-29.
  3. Deng Jing Zhen, et al. Experimental research on animal’s rectally with Zhong Yao Tang Ji. Traditional Chinese Medicine Bulletin. 1986;11(5):30-32.
  4. Xie Kuo, et al. Qing Wen Bai Du Ying’s therapeutic effect and mechanism on rabbit’s intense heat in both qi and blood systems resulting from endotoxin of Bacillus coli. China Journal of Integrated Medicine. 1993;13(2):94-97,69.
  5. Deng Jing Zhen, et al. Preparation and pharmacological effects of rectal administration of Qing Weng Bai Du San. Journal of Traditional Chinese Medicine Information. 1986;(3):28-29.
  6. Xing Cong, et al. Observation on treating various drug-tolerant typhoid and T-lymphocyte sub-population with modified Qing Wen Bai Du Yin. Journal of New TCM. 1997;29(10):10-12.
  7. Yu Jian Er, et al. Treating child infectious mononucleosis with modified Qing Wen Bai Du Yin. Shanghai Journal of Traditional Chinese Medicine and Herbs. 2000;34(6):24-25.
  8. Xing Cong, et al. Treating 22 cases of multiple drug-tolerant typhoid with modified Qing Wen Bai Du Yin. China Journal of Integrated Medicine. 1998;18(1):45.
  9. Zhao Jin Lan. Treating epidemic hemorrhagic fever with modified Qing Wen Bai Du Yin. Shandong Journal of TCM. 1998;17(4):161.
  10. Wang Xi Chu, et al. Treating 20 cases of severe allergic skin rash cased by aminobenzylpenicillin with modified Qing Wen Bai Du Yin. Intermediate Journal of Medicine. 1995;30(9):51-52.
  11. Wang Yu Ru. Treating acute psoriasis of erythroderma type by Qing Wen Bai Du Yin Plus. Journal of Integrated Medicine of First Aid Clinical Application. 1995;2(5):202-203.