She Dan Chuan Bei San

Functions

She Dan Chuan Bei San expels pathogenic wind, relieves coughing, and removes phlegm. The formula is mainly used to treat cough due to lung-heat, abundant expectoration, short breath, and cough with yellow sticky phlegm.

Dosage Info

Oral Powder: 0.3g per bottle, 0.3-0.6g each time, 2-3 times a day. The liquid is orally taken as one dose, 3 times a day. The capsule is orally taken as 2 capsules, 3 times a day. 5:1 concentrated extracts: 9 grams/day

Ingredients

Precautions

The formula can occasionally cause rashes and allergic reactions. (1) , (2) , (3) , (4) It is prohibited from being taken by patients with cough due to wind and cold, accumulation of phlegm-dampness in the lung, lingering cough due to weakness, and loose stool.

Pharmacology

Inhibitive effect on central nervous system: In mice, this formula can significantly reduce the amount of voluntary behavior in mice, extend convulsion, and delay death due to strychnine, thus having a significant inhibiting effect on the central nervous system. (5)

Relieving cough and removing phlegm: This formula can significantly reduce the number of coughs caused by ammonia water in guinea pigs and increase the excretion of phenol red in mice trachea. (6)

In vitro antiseptic effect: There has been research into the in vitro antiseptic activities of She Dan Chuan Bei. The Kirby-Beuer paper diffusion and agar gel dilution methods were used to carry out sensitivity tests on Staphylococcus aureus, Bacillus coli, Klebsiella pneumoniae, pneumococcus, and beta hemolytic streptococcus. As a result, the diameter of a circle for She Dan Chuan Bei Ye and its diluted solution (1:10) to inhibit beta hemolytic streptococcus is 24 and 12mm respectively. These results showed that She Dan Chuan Bei Ye has certain antiseptic activities on beta hemolytic streptococcus. (7)

Clinical Applications

Treating bronchitis
304 cases of chronic bronchitis were treated with She Dan Chuan Bei. The overall effectiveness rate was 88.52%. The cough-relieving effectiveness rate was 91.30%, the phlegm-removing effectiveness rate was 91.57%, and the asthma-relieving effectiveness rate was 75%. 30 cases of acute or chronic bronchitis, due to phlegm and heat in traditional Chinese medicine, were treated with Dan Bei capsules and She Dan Chuan Bei capsules for a double-blind contrast. As a result, the symptoms were significantly improved in both groups, and both experienced similar therapeutic effects. This showed that both capsules have the ability to clear heat, remove phlegm, relieve cough, and both have certain therapeutic effects on cough due to phlegm and heat. (8)

The formula She Dan Chuan Bei powder was used to treat 343 cases of acute and chronic bronchitis, inflammation of upper respiratory tract, and cough. The formula contained She Dan (Snake Bile), Chuan Bei Mu (Sichuan Fritillary Bulb), Qi Ye Yi Zhi Hua (Birthwort Fruit), Ma Dou Ling (Aristolochia Fruit), Ban Xia (Pinellia Tuber), and Gan Cao (Licorice Root). The total effectiveness rate was 90.37%. (9)

Treating recurrent aphtha
The powdered formula was orally administered and externally applied to treat 2 cases of lingering aphtha. Pain was alleviated and the ulcerations were resolved after 3 and 10 days of treatment, respectively. No relapses occurred in a 3-month follow-up visit. (10)

Treating chronic pharyngitis
30 cases of chronic pharyngitis were treated for 6 days as one course of treatment. The total effectiveness rate was 93.3%. (11)

Treating uterine neck wound’s surface bleeding:
52 cases were treated with this formula. The herbs used included She Dan Chuan Bai San, with Qing Dai (Natural Indigo), Ming Fan (Alum), Pu Huang Tan (Cattail Pollen), Huang Qi (Astragalus Root), and a small amount of crushed borneol. Routine sterilization was carried out for the vagina and the neck of the uterus. The well-mixed powder was applied to the uterine neck wound’s surface once a day until the bleeding ceased. The results showed significant effectiveness in 48 cases and improvement in 4 cases. When re-examination was carried out on 40 patients 6 months later, no reoccurring bleeding was found on the wound surfaces. (12)

Treating infantile pneumonia
100 cases of infantile pneumonia were treated with She Dan Chuan Bei San in coordination with routine therapy using antibiotics, cough-relieving drugs, and hormone and oxygen-inhale. 80 cases in a comparison group were treated with only the routine therapy. The results showed that the total effectiveness rates were 85% and 67.5% respectively in the two groups. (13)

References

  1. Li Xue Yi. She Dan Chuan Bei Ye induced one case of drug rash. Traditional Chinese Medicine Bulletin. 1987;(10):54.
  2. Zhou Wen Wu, et al. Oral administration of She Dan Chuan Bei Ye induced one case of drug rash. China Journal of Dermatology and Venereology. 1990;4(1):42.
  3. Yang Shu Xan. She Dan Chuan Bei Ye induced one case of allergic reaction. Beijing Journal of TCM. 1992;(2):54.
  4. Chen Yu Pei. Oral administration of She Dan Chuan Bei Ye induced 2 cases of allergic reaction. Sichuan Journal of TCM. 1992;10(9):26.
  5. Wang Zhong Duan, et al. Research on She Dan Chuan Bei Ye’s effect on the central nervous system. Journal of Chinese Patented Medicine. 1991;13(11):49.
  6. Tian Yu Wang, et al. Research on She Dan Chuan Bei Ye’s effect in relieving cough, removing phlegm, and relieving asthma. Journal of Chinese Patented Medicine. 1993;15(3):28-29.
  7. Li Yang, et al. Research on in vitro anti-bacterial effect of total glycosides of Bei Mu from Ning Xia region and She Dan Chuan Bei Ye. Ninxia Journal of Medicine. 1996;18(3):147-148.
  8. Zhu Wei Xing, et al. Treating 30 cases of chronic bronchitis, belonging to cough due to phlegm and heat in traditional Chinese medicine with Dan Bei Capsules. Journal of New TCM. 1995;27(11): 24,20.
  9. Guo Yao Guang. Clinical therapeutic analysis of the formula She Dan Chua Bei. Guangzhou Journal of Medicine. 1987;(4):49-50.
  10. Yan Fu Ming, et al. Treating two cases of recurrent aphtha with She Dan Chuan Bei San. Journal of Chinese Patented Medicine Research. 1987;(8):43.
  11. Yu Jian Ping. Treating 30 cases of chronic pharyngitis with She Dan Chuan Bei San. Journal of Integrated Medicine. 1988;8(8):503.
  12. Chen Li Juan, et al. Treating 52 cases of uterine neck wound’s surface bleeding with modified She Dan San. Journal of Integrated Medicine. 1990;10(5):308-309.
  13. Gao Bao Gui, et al. She Dan Chuan Bei Ye had significant effect in assisting treatment for infant pneumonia. Jilin Journal of TCM. 1991;(4): 34.