Tocotrienols

Introduction

Tocotrienols consist of four different compounds that are members of the vitamin E family. Scientists refer to these as alpha, beta, gamma, and delta tocotrienol and they are generally sold together in dietary supplements. Some studies suggest that these four tocotrienols may be more potent than vitamin E for protection against elevated cholesterol, oxidation of LDL cholesterol and atherosclerosis.

Only small quantities of tocotrienols are available through foods. Barley, rice bran, and palm oil products contain limited amounts of tocotrienols. However, most people in the United States do not consume enough of these foods to obtain meaningful amounts of tocotrienols.

Dosage Info

Dosage Range

35mg to 325mg daily.

Most Common Dosage

40 to 50mg of mixed tocotrienols daily.

Dosage Forms

capsules, tablets, emulsified liquids.

Interactions and Depletions

Interactions

Reported Uses

As mentioned, tocotrienols may reduce the buildup of atherosclerotic plaque in the blood vessels. In addition to potentially reducing cholesterol levels, tocotrienols may further support cardiovascular health by reducing the oxidation of cholesterol, which can further damage blood vessels. (1) , (2)

Several other studies suggest that tocotrienols may aid in the treatment of cancer. More specifically, tocotrienols may inhibit breast cancer cells (3) and may be of possible benefit when used with the prescription drug tamoxifen. (4) It may also be useful in the treatment of liver cancers and melanoma. (5) , (6)

Toxicities & Precautions

Introduction

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General

This dietary supplement is considered safe when used in accordance with proper dosing guidelines.

Pregnancy / Breast Feeding

To date, the medical literature has not reported any adverse effects related to fetal development during pregnancy or to infants who are breast-fed. Yet little is known about the use of this dietary supplement while pregnant or breast-feeding. Therefore, it is recommended that you inform your healthcare practitioner of any dietary supplements you are using while pregnant or breast-feeding.

Age Limitations

To date, the medical literature has not reported any adverse effects specifically related to the use of this dietary supplement in children. Since young children may have undiagnosed allergies or medical conditions, this dietary supplement should not be used in children under 10 years of age unless recommended by a physician.

References

  1. View Abstract: Tomeo A, et al. Antioxidant Effects of Tocotrienols in Patients With Hyperlipidemia and Carotid Stenosis. Lipids. 1995;30(12):1179-1183.
  2. View Abstract: Qureshi A, et al. Response of Hypercholesterolemic Subjects to Administration of Tocotrienols. Lipids. 1995;30(12):1171-1177.
  3. View Abstract: Nesaretnam K, et al. Effect of tocotrienols on the growth of a human breast cancer cell line in culture. Lipids. Dec1995;30(12):1139-43.
  4. View Abstract: Nesaretnam K, Dorasamy S, Darbre PD. Tocotrienols inhibit growth of ZR-75-1 breast cancer cells. Int J Food Sci Nutr. 2000;51(Suppl):S95-103.
  5. View Abstract: Rahmat A, et al. Long-term administration of tocotrienols and tumor-marker enzyme activities during hepatocarcinogenesis in rats. Nutrition. May1993;9(3):229-32.
  6. View Abstract: He L, et al. Isoprenoids suppress the growth of murine B16 melanomas in vitro and in vivo. J Nutr. May1997;127(5):668-74.