Xiao Yin Pian

Functions

Xiao Yin Pian functions to remove pathogenic heat from the blood, to ameliorate dryness by enriching the blood, and to relieve itchiness by dispelling wind. It is primarily used to treat psoriasis.

Dosage Info

Pill: orally taken 0.3g per pill, 5-7 pills each time, 3 times a day. 1-3 months constitute one course of treatment. 5:1 concentrated extract: 9 grams/day.

Ingredients

• Fang Feng
• Jin Yin Hua
• Chi Shao
• Da Qing Ye
• Di Huang
• Ku Shen

Precautions

Toxicity: LD₅₀ (mice/abdominal injection): 8.956g/ kg.
Side Effects: There has been a report of 2 cases of male sexual dysfunction after taking Xiao Yin Wan. (1)

Pharmacology

Counteracting allergic reaction: Administered to guinea pigs by endogastric infusion at 8g/kg, Xiao Yin Pian is shown to prolong the latency of histamine-induced asthma. At 5g/kg, the formula can delay the onset of allergic reaction symptoms brought on by bovine serum, and significantly reduce the occurrence rate of allergic reaction. (2)

Anti-inflammatory effects: Fed to mice at 1-4g/kg, Xiao Yin Pian has a significant inhibitory effect on xylol-induced increase in auricular capillary permeability. Administered to mice by endogastric perfusion at 4g/kg, it can significantly inhbit egg albumin-induced foot edema. (3)

Clinical Applications

Psoriasis
Li, et al. treated about 200 cases of psoriasis with Xiao Yin Pian. The results: 47.6% of the patients were resolved, 35.7% improved, and the remaining 16.7% did not respond to the treatment, with a total effective rate of 83.3%. On average, the patients recovered in 54.4 days. (4)

References

1. Tong Ming, et al. 2 cases of male sexual dysfunctions after oral administration of Xiao Yin Pian. Journal of New Medicine and Clinical Application. 1995;14(1):56.
2. Li Feng Lin, et al. Xiao Yin Pian’s anti-allergic effects. Journal of Pharmacology and Clinical Application of TCM. 1988;491:35-36.
3. Gao Yun Rui, et al. Xiao Yin Pian’s anti-inflammatory effects. Journal of Pharmacology and Clinical Application of TCM. 1990;6(3):43-44.
4. Li Feng Lin, et al. The mechanism by which Xiao Yin Pian treats psoriasis. Journal of Chinese Materia Medica. 1988;19(10):462-463.