Yu Quan Wan

Functions

According to traditional Chinese medicine, this formula nourishes yin, tonifies the kidney, reduces inner fire, balances inner energy, and boosts energy. This is used for diabetes with deficency in lung, stomach and kidney energy.

Dosage Info

Concentrated pills: 1.5g every 10 pieces, adults take 9g (60pieces) each time, 4 times a day. Children seven years old or older taken half of adult dosage. Children between 3-7 years old take 1/3 of adult dosage. Capsules: 1-2 capsules each time, 3 times a day, or as directed. Infusion: 1 bag each time, 3 times a day, orally taken. Powder: 9-15g each time, 1-3 times a day. 5:1 concentrated extract: 9 grams/day.

Ingredients

Precautions

Toxicity: Administered by hypodermic injection to rats under anesthesia, Yu Quan Wan at the dosage of 20g/kg does not significantly affect the subject’s EKG, heartbeat, blood pressure, or breathing. When changed to duodenum administration, however, Yu Quan Wan at the dosage of 50g/kg does slightly lower the subject’s blood pressure and moderately quickens breathing in the initial stage of treatment. Oral feeding mice Yu Quan Wan at the dosage of 35g/kg per day for two consecutive days shows no poisoning signs (1)

General: Avoid hot/spicy food while taking this formula.

Side Effects: Su Bo (2) reported one case of adverse reaction: A female patient, aged 41, showed slight heart palpitation, short breath, and chest congestion after taking Yu Quan Wan (3)

Pharmacology

This formula’s main pharmacological actions include lowering blood sugar levels, lowering blood fat levels, and counteracting oxidation.

Lowering blood sugar: Experiments show that administered at the dosage of 25g/kg for four consecutive days, Yu Quan Wan can significantly lower the blood sugar level in rats with adrenaline-induced high blood sugar levels. Similarly, administered at the dosage of 50g/kg for 30 consecutive days, the formula can significantly lower the blood sugar level in rats with alloxan-induced high blood sugar levels. (4) Within two hours after mice are fed with Yu Quan Wan at the dosage of 6.75g/kg, their blood sugar level can be lowered by 13.5% and this effect can last up to 5-6 hours, an effect comparable to that of insulin at the dosage of 1.02u/kg or that of D860 at the dosage of 60mg/kg. (5)

Yu Quan Wan’s blood sugar-lowering effect has been further validated in experiments on mice and rabbits, using other forms of the formula (e.g., instant tea and capsules). (6) , (7)

Lowering blood fat and counteracting oxidation: Fed to quails with artificially induced high blood fat levels, Yu Quan Wan tablets can significantly lower the total cholesterol level in the subject’s serum and significantly increase the high-density lipoprotein level. Furthermore, compared to the control group, the treatment group also shows a significantly lower level of oxidation, a decrease in liver weight, and an increase in genital gland. (8)

Clinical Applications

Hormone withdrawal rebound syndrome
This formula is mainly used to treat diabetes and hormone withdrawal rebound syndrome, a syndrome caused by the withdrawal and reduced use of hormones. He Yu Lan has used Yu Quan Wan to treat hormone withdraw rebound syndrome and reported satisfactory results. (9)

Diabetes
Jia has treated 54 patients with diabetes using Yu Quan Wan as the base formula, adding or subtracting ingredients as a particular case warrants. Forty-two cases resolved, 10 cases improved, and 2 cases had no response, tallying an overall effective rate of 96.3%. (10)

Wang Zhong Xue, et al. have used Yu Quan Wan to treat 6 cases of lipogenous diabetes and reported satisfactory results. (11)

Li, et al. have used Yu Quan Wan to treat 18 typical diabetes cases for a duration of two months and reported that 6 cases significantly improved, 7 cases improved, and 5 cases had no response. (12)

References

  1. Yi Mu Yuan. Journal of Chinese Patent Medicine Research. 1982;(4):27.
  2. Su Bo. Hebei Journal of Traditional Chinese Medicine. 1991;12(4):21.
  3. Su Bo. Hebei Journal of Traditional Chinese Medicine. 1991;12(4):21.
  4. Yi Mu Yuan. Journal of Chinese Patent Medicine Research. 1982;(4):27.
  5. Meng Qing Di. Chinese Medicine Bulletin. 1982;(6):32.
  6. Yang Ji Fan, et al. Journal of Chinese Patent Medicine Research. 1993;15(8):26-27.
  7. Wang Xin Ming, et al. Journal of Chinese Patent Medicine. 1992;14(1):29.
  8. Qian Qiu Hai, et al. Journal of Shandong College of Traditional Chinese Medicine. 1992;16(2):133-135.
  9. He Yu Lan. Jilin Journal of Traditional Chinese Medicine. 1986;(5):18.
  10. Jia Xiu Xia. Journal of TCM Correspondence School of Shanxi. 1996;(6):21-22.
  11. Wang Zhong Xue, et al. Journal of Changchun College of Traditional Chinese Medicine. 1994;10(4):20.
  12. Li Zong Cai, et al. Journal of Traditional Chinese Medicine. 1984;25(2):71.