A novel peptide isolated from the leaves of Gymnema sylvestre–I. Characterization and its suppressive effect on the neural responses to sweet taste stimuli in the rat.


Author

Imoto T, Miyasaka A, Ishima R , Akasaka K

Date

1991

Journal

Comp Biochem Physiol A

Abstract

1. A new substance that suppressed selectively the neural responses of the rat to sweet taste stimuli was isolated from the leaves of Gymnema sylvestre. 2. The substance was proved to be a peptide consisting of 35 amino acids and having a molecular weight of about 4,000. 3. The inhibitory effect on the sweet responses appeared after treating the tongue surface with the peptide at a concentration of more than 1 x 10(-6) M.

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