Extract Standardization

The aim of extract standardization is to yield a standardized extract. Standardized extract is an active constituents isolated from herbs and concentrated to a specific, guaranteed quality product and expressed as percentage.

Extract Standardization

Steps Aims
Medicinal plant discoveryBotanical studyMorphological investigation of medicinal plant including macroscopic and microscopic studies. Literature review based on monograph or pharmacopoeia. Authentication of medicinal plant.
Extract preparationPhytochemical investigationDetermination of raw material preparation method. Standardization of extraction method. Composition analysis. Characterization of purity, impurities and contaminants. Determination of marker compound or active constituent.
Extract fractionationIdentification of marker compound or active constituentAnalysis of marker compound or active constituent for preliminary identification. Structural elucidation of compounds in extract preparation.
Chemical characterizationPhysico chemical propertiesChemical identification of marker compund or active constituents by fingerprinting (chromatogram, spectroscopic etc.) Quantification of marker compound or active constituent. Physico chemical property measurements of marker compound/active constituent and extract. Physical and chemical characterization of extract. Structural elucidation of marker compound or active constituent. Standardization of herbal extract.
Primary pharmacodynamic studyBiological characterizationScreening of pharmacology or therapeutic effect.
Note: Definitions were quoted from [1], [2] and [3].
in this scope
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