Hypoglycemic activity of polypeptide-p from a plant source.


Author

Khanna P, Jain SC, Panagariya A

Date

11/1981

Journal

J Nat Prod

Abstract

A hypoglycemic peptide, Polypeptide-p, has been isolated from fruit, seeds, and tissue of Momordica charantia Linn (bitter gourd). Amino acid analysis indicates a minimum molecular weight of approximately 11,000 (166 residues). Polypeptide-p is a very effective hypoglycemic agent when administered subcutaneously to gerbils, langurs, and humans.

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