Author
Wattanapitayakul, S. K., Suwatronnakorn, M., Chularojmontri, L., Herunsalee, A., Niumsakul, S., Charuchongkolwongse, S., Chansuvanich, N.
Journal
J Ethnopharmacol
Volume
110
Issue ID
3
Page
559-62
Date
2007 Apr 4.
Keyword
Alternative medicine
Dose-Response Relationship, Drug
Endothelial Cells/drug effects*
Endothelial Cells/metabolism
Gene Expression Regulation/drug effects*
Humans
Medicine, Oriental Traditional
Nitric Oxide/biosynthesis
Nitric Oxide Synthase Type II/drug effects
Nitric Oxide Synthase Type II/genetics
Nitric Oxide Synthase Type III/drug effects
Nitric Oxide Synthase Type III/genetics
Nitrites/metabolism
Phytotherapy
Plant Extracts/chemistry
Plant Extracts/pharmacology*
Plants, Medicinal/chemistry
RNA, Messenger/drug effects
Rhizome
Thailand
Umbilical Veins/cytology
Umbilical Veins/metabolism
Zingiberaceae/chemistry*
Abstract
The rhizomes of Kaempferia parviflora (KP) (Zingiberaceae) have been used in Thai traditional medicine for health promotion and for the treatment of digestive disorders and gastric ulcer. This study investigated effect of KP on endothelial function. Studies in human umbilical vein endothelial cells (HUVEC) showed that KP dose-dependently increased nitrite concentrations in culture media after 48 h incubation. eNOS mRNA and protein expression were also enhanced. The induction of eNOS mRNA was detected at 4 h and plateau at 48 h while iNOS expression was not observed. These data demonstrate that KP has a great potential for a supplemental use in vascular endothelial health promotion.
Language
eng
