Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. I. Clinical results of a multicenter, randomized, double- blind, placebo-controlled trial. The IFNB Multiple Sclerosis Study Group
Author Date 4/1993 Journal Neurology Abstract We report a multicenter, randomized, double-blind, placebo-controlled trial of interferon beta-1b (IFNB) in 372 ambulatory patients with relapsing-remitting multiple sclerosis (MS). Entry criteria included an Expanded Disability Status Scale (EDSS) score of 0 to 5.5 and at least two exacerbations in the previous 2 years. One-third of the patients […]
Trial of a new medium-term model using benzo(a)pyrene induced lung tumor in newborn mice.
Author Yun TK, Kim SH, Lee YS Date 5/1995 Journal Anticancer Res Abstract A new medium-term in vivo model was tried using pulmonary adenoma induced by benzo(a)pyrene (BP) in newborn mice. Both inbred mice such as C57BL/5J, C57BR/cdJ. A/J mice and non inbred N:GP(S) mice were used. Benzo(a)pyrene was injected in the subscapular region of […]
Pharmacological properties of Dibenzo[a,c]cyclooctene derivative isolated from Fructus Schizandrae Chinensis III. Inhibitory effects on carbon tetrachloride-induced lipid peroxidation, metabolism and covalent binding of carbon tetrachloride to lipids.
Author Liu KT, Lesca P Date 15/7/1982 Journal Chem Biol Interact Abstract Fructus Schizandrae, a traditional Chinese tonic, has been shown to lower the elevated serum glutamic pyruvic transaminase (SGPT) levels of patients with chronic viral hepatitis and several of its components decrease the hepatotoxicity of carbon tetrachloride (CCl4) in animals. This paper deals with […]
Thyroid autoimmunity and aging.
Author Mariotti S, Chiovato L, Franceschi C, Pinchera A. Date 9/1998 Journal Exp Gerontol Abstract Aging is associated with the appearance of several serum autoantibodies, including thyroid autoantibodies. The biological and clinical significance of this phenomenon is still unknown, because, with the exception of primary myxedema, the prevalence of clinically overt thyroid autoimmune diseases is […]
Serum antioxidants and age-related macular degeneration in a population-based case-control study.
Author Mares-Perlman JA, Brady WE, Klein R Date 12/1995 Journal Arch Ophthalmol Abstract OBJECTIVE: To investigate relationships between levels of tocopherols and carotenoids in the serum and age-related macular degeneration (ARMD). DESIGN: A nested case-control study within a population-based cohort. PARTICIPANTS: Cases included a sample of subjects with retinal pigment abnormalities with the presence of […]
Antiexudative and capillaritonic effects of procyanidines isolated from grape seeds (V. Vinifera).
Author Zafirov D, Bredy-Dobreva G, Litchev V Date 1990 Journal Acta Physiol Pharmacol Bulg Abstract A purified and enriched fraction, containing procyanidines, was isolated from grape seeds of Bulgarian sorts of Vitis Vinifera. The effects of procyanidines on the local oedema, produced by subplantar injection of carrageenin and dextran in the hind rat paw, were […]
Evaluation of antioxidant activity by chemiluminescence.
Author Hirayama O, Takagi M, Hukumoto K Date 1/5/1997 Journal Anal Biochem Abstract A sensitive and simple chemiluminescent method for measuring antioxidant activity was developed. The method is based on antioxidant-dependent quenching of chemiluminescence generated from lipid hydroperoxide and isoluminol/microperoxidase reagent. This method was used to evaluate the antioxidant ability of various antioxidants by measuring […]
Gynecologic conditions and bacterial vaginosis: Implications for the non-pregnant patient
Author Sweet RL Date 2000 Journal Infect. Dis. Obstet. Gynecol Abstract Bacterial vaginosis is characterized by a shift from the predominant lactobacillus vaginal flora to an overgrowth of anaerobic bacteria. Bacterial vaginosis is associated with an increased risk of gynecologic complications, including pelvic inflammatory disease, postoperative infection, cervicitis, human immunodeficiency virus (HIV), and possibly cervical […]
The effect of procyanidolic oligomers on mesenchymal cells in culture. II–Attachment of elastic fibers to the cells
Author Robert AM, Groult N, Six C, Robert L Date 6/1990 Journal Pathol Biol (Paris) Abstract Tissues are composed of cells and extracellular matrix (EM). Adhesion of cells to extracellular matrix is mediated by membrane-bound glycoproteins such as fibronectin, laminin and others. Elastonectin was shown recently to be involved in the mediation of interactions between […]
Epidemiology of chronic venous insufficiency
Author Carpentier P, Priollet P Date 10/2/1994 Journal Presse Med Abstract From an epidemiological point of view, at least three different entities of chronic venous insufficiency (CVI) can be defined: heavy legs syndrome is experienced by about half the working people of industrialized countries. It is most frequently linked to varicosis, nevertheless, in one case […]
