Histamine induces migraine via the H1-receptor. Support for the NO hypothesis of migraine.
Author Lassen LH, Thomsen LL, Olesen J. Date 7/1995 Journal Neuroreport Abstract In primates, histamine activates cerebral endothelial H1-receptors leading to formation of nitric oxide (NO). Twenty migraine patients received pretreatment with placebo or the histamine-H1-receptor antagonist, mepyramine, in a randomized, double blind fashion, followed in both groups by i.v. histamine (0.5 microgram kg-1 min-1 […]
Vitamin D and calcium in menstrual migraine.
Author Thys-Jacobs S Date 10/1994 Journal Headache Abstract Two premenopausal women with a history of menstrually-related migraines and premenstrual syndrome were treated with a combination of vitamin D and elemental calcium for late luteal phase symptoms. Both cited a major reduction in their headache attacks as well as premenstrual symptomatology within 2 months of therapy. […]
Kava-kava extract WS 1490 versus placebo in anxiety disorders–a randomized placebo-controlled 25-week outpatient trial.
Author Volz HP, Kieser M Date 1/1997 Journal Pharmacopsychiatry Abstract 101 outpatients suffering from anxiety of non-psychotic origin (DSM- III-R criteria: agoraphobia, specific phobia, generalized anxiety disorder, and adjustment disorder with anxiety) were included in a 25- week multicenter randomized placebo-controlled double-blind trial with WS 1490, a special extract of kava-kava. In the main outcome […]
Antidiabetic effect of a leaf extract from Gymnema sylvestre in non-insulin-dependent diabetes mellitus patients.
Author Baskaran K, Kizar Ahamath B, Radha Shanmugasundaram K Date 10/1990 Journal J Ethnopharmacol Abstract The effectiveness of GS4, an extract from the leaves of Gymnema sylvestre, in controlling hyperglycaemia was investigated in 22 Type 2 diabetic patients on conventional oral anti-hyperglycaemic agents. GS4 (400 mg/day) was administered for 18-20 months as a supplement to […]
Demonstration of the hypoglycemic action of Momordica charantia in a validated animal model of diabetes.
Author Sarkar S, Pranava M, Marita R Date 1/1996 Journal Pharmacol Res Abstract In an effort to establish and document the hypoglycaemic activity of Momordica charantia in validated models of diabetes, the alcoholic extract of the pulp was studied. In the normal glucose primed rat model, M. charantia fruit extract, 500 mg kg-1, depressed the […]
L-arginine infusion promotes nitric oxide-dependent vasodilation, increases regional cerebral blood flow, and reduces infarction volume in the rat.
Author Morikawa E, Moskowitz MA, Huang Z Date 2/1994 Journal Stroke Abstract BACKGROUND AND PURPOSE: We previously reported that L-arginine infusion increased pial vessel diameter by nitric oxide-dependent mechanisms, improved regional cerebral blood flow (rCBF) distal to middle cerebral artery (MCA) occlusion, and reduced infarction volume in spontaneously hypertensive rats when administered intraperitoneally before and […]
Defective 3,4-dihydroxyphenylalanine decarboxylation to dopamine in hydralazine-treated hypertensive patients may be pyridoxine remediable
Author Shigetomi S, Kuchel O Date 1/1993 Journal Am J Hypertens Abstract The previously observed defective dopamine (DA) generation from 3,4- dihydroxyphenylalanine (DOPA) can also be seen in patients treated for many years by hydralazine. This may be due to a hydralazine- induced depletion of pyridoxine, an essential coenzyme of the aromatic L-amino acid decarboxylase […]
The slow discovery of the importance of omega 3 essential fatty acids in human health .
Author Holman RT Date 2/1998 Journal J Nutr Abstract Although linoleic and linolenic acids have been known to be necessary for normal growth and dermal function since 1930, the omega 3 essential fatty acids (EFA) have not received much attention until recently. The two families of acids are metabolized by the same enzymes, making them […]
Positive Modulating Action of Shengmaisan with Astragalus membranaceus on Anti-tumor Activity of LAK Cells.
Author Zhao KS Date 11/1990 Journal Immunopharmacology Abstract Enhancing the anti-tumor activity of LAK cells is one of problems which are expected to be solved in tumor clinic at present. The effects of Shengmaisan with Astragalus membranaceus (SMAM) on anti-tumor activity of LAK cells with the 3H release assay were studied. The LAK cells taken […]
Agnus castus extracts inhibit prolactin secretion of rat pituitary cells.
Author Sliutz G, Speiser P, Schultz AM Date 5/1993 Journal Horm Metab Res Abstract In our studies on prolactin inhibition by plant extracts we focused on the effects of extracts of Vitex agnus castus and its preparations on rat pituitary cells under basal and stimulated conditions in primary cell culture. Both extracts from Vitex agnus […]
