Mechanisms of platelet-induced angiospastic reactions: potentiation of calcium sensitivity.
Author Akopov SE, Zhang L, Pearce WJ Date 7/1997 Journal Can J Physiol Pharmacol Abstract Platelet aggregation and adherence to the vessel lumina are common events in various physiological and pathological conditions. However, the mechanisms whereby aggregating platelets cause vasoconstriction remain unclear. We hypothesized that aggregating platelets may alter the Ca2+ sensitivity of the contractile […]
Stimulation of collagen synthesis in fibroblast cultures by a triterpene extracted from Centella asiatica.
Author Maquart FX, Bellon G, Gillery P Date 1990 Journal Connect Tissue Res Abstract The drug “Titrated Extract from Centella asiatica” (TECA), used for its stimulating properties on the healing of wounds, is a mixture of 3 terpenes extracted from a tropical plant: asiatic acid (30%, w/w), madecassic acid (30%, w/w) and asiaticoside (40%, w/w). […]
Extreme hypermagnesemia as a cause of refractory hypotension.
Author Mordes JP, Swartz R, Arky RA. Date 11/1975 Journal Ann Intern Med Abstract A 62-year-old woman with adequate renal function who consumed large quantities of magnesium citrate presented with lethargy and hypotension. The hypotension was refractory to all conventional therapy. Her serum magnesium was 12.5 meq/litre (normal, 1.5 to 2.5). She was found to […]
Phytic acid in health and disease.
Author Zhou JR, Erdman JW Jr. Date 11/1995 Journal Crit Rev Food Sci Nutr Abstract Phytic acid (PA), a major phosphorus storage compound of most seeds and cereal grains, contributes about 1 to 7% of their dry weight. It may account for more than 70% of the total kernel phosphorus. PA has the strong ability […]
Effects of extended systemic and topical folate supplementation on gingivitis of pregnancy.
Author Thomson ME, Pack AR Date 5/1982 Journal J Clin Periodontol Abstract A former double-blind study evaluated the effect of a 14-day period of systemic and topical folate supplementation on gingival inflammation during pregnancy (Pack & Thomson 1980). The current experiment was similar to the earlier one except that supplementation was for 28 days during […]
How to characterize an antioxidant: an update.
Author Halliwell B Date 1995 Journal Biochem Soc Symp Abstract The term antioxidant is widely used but rarely defined. One suggested definition is that an antioxidant is ‘a substance that, when present at low concentrations compared with those of an oxidizable substrate, significantly delays or prevents oxidation of that substrate’. Many substances have been suggested […]
Role of magnesium in the pathogenesis and treatment of migraines.
Author Mauskop A, Altura BM. Date 1998 Journal Clin Neurosci Abstract The importance of magnesium in the pathogenesis of migraine headaches is clearly established by a large number of clinical and experimental studies. However, the precise role of various effects of low magnesium levels in the development of migraines remains to be discovered. Magnesium concentration […]
A comparison of the effects of an extract of feverfew and parthenolide, a component of feverfew, on human platelet activity in-vitro.
Author Groenewegen WA, Heptinstall S. Date 8/1990 Journal J Pharm Pharmacol Abstract Extracts of the herb feverfew inhibit human blood platelet aggregation and secretion induced by a number of agents in-vitro and this may relate to the beneficial effects of feverfew in migraine. We previously identified several compounds with antisecretory activity in human blood platelets […]
Effects of oxazepam and an extract of kava roots (Piper methysticum) on event-related potentials in a word recognition task.
Author Munte TF, Heinze HJ, Matzke M, Steitz J Date 1993 Journal Neuropsychobiology Abstract Twelve healthy volunteers were tested in a double-blind crossover study to assess the effects of oxazepam and an extract of kava roots (Piper methysticum) on behavior and event-related potentials (ERPs) in a recognition memory task. The subjects’ task was to identify […]
Possible regeneration of the islets of Langerhans in streptozotocin- diabetic rats given Gymnema sylvestre leaf extracts.
Author Shanmugasundaram ER, Gopinath KL, Radha Shanmugasundaram K Date 10/1990 Journal J Ethnopharmacol Abstract Two water soluble extracts, GS3 and GS4, obtained from the leaves of Gymnema sylvestre, were tested in streptozotocin treated rats for their effects on blood glucose homeostasis and pancreatic endocrine tissue. In the diabetic rats, fasting blood glucose levels returned to […]
