How 5-Hydroxytryptophan (5-HTP) interacts with St. John’s wort

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Interaction rating:

Studies report that 5-HTP may act in the body like this supplement, which may alter the effects of this supplement and possibly the dose needed for treatment. Use with caution. (1)


  1. View Abstract: Kahn RS, et al. L-5-hydroxytryptophan in the Treatment of Anxiety Disorders. J Affect Disord. Mar1985;8(2):197-200.