Aloe Vera : interactions with antidiabetic medications

Interaction type: Interactions

Interaction rating: Potential/Theoritical
Aloe has the ability to lower blood sugar and thus may alter the effect and possibly the dose of these medications. Use with caution. (1)
These drugs include Insulin, glyburide, glipizide, metformin, rosiglitazone, pioglitazone, glimepiride, tolbutamide, tolazamide, acarbose, acetohexamide, chlorpropamide, miglitol, repaglinide, nateglinide

Clinical evidence

In placebo-controlled clinical study conducted found aloe vera juice (80% aloe vera juice with additional flavours and preservatives), taken twice daily orally with glibenclamide for 42 days, reduce blood-glucose (from 14 to 16 mmol/L down to 8 mmol/L over 6 weeks period) in patients with diabetes compared to control group (patient treated with glibenclamide only).(2)(3)


  1. View Abstract: Ajabnoor MA. Effect of aloes on blood glucose levels in normal and alloxan diabetic mice. J Ethnopharmacol. Feb1990;28(2):215-20.
  2. Bunyapraphatsara N, Yongchaiyudha S, Rungpitarangsi V, Chokechaijaroenporn O. Antidiabetic activity of Aloe vera L. juice II. Clinical trial in diabetes mellitus patients in combination with glibenclamide. Phytomedicine. 1996 Nov 1;3(3):245-8
  3. Yongchaiyudha S, Rungpitarangsi V, Bunyapraphatsara N, Chokechaijaroenporn O. Antidiabetic activity of Aloe vera L. juice. I. Clinical trial in new cases of diabetes mellitus. Phytomedicine. 1996 Nov 1;3(3):241-3.