How Arginine interacts with ACE inhibitors

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These medications and intravenous arginine infusions both can cause high potassium levels in the blood. Intravenous arginine infusions can only be performed by licensed healthcare professionals and are used to test for growth hormone deficiency and for the treatment of metabolic alkalosis. Arginine infusions should be used with caution in individuals who are on ACE inhibitors. (1) (2) These drugs include benazepril, captopril, enalapril, lisinopril, fosinopril,moexipril, quinapril, ramipril, trandolapril, perindopril erbumine.


  1. View Abstract: Massara F, Martelli S, Ghigo E, et al. Arginine-induced Hypophosphatemia and Hyperkaliemia in Man. Diabete Metab. Dec1979;5(4):297-300.
  2. View Abstract: Piepho RW. Overview of the Angiotensin-converting-enzyme Inhibitors. Am J Health Syst Pharm. Oct2000;57(Suppl 1):S3-7.