Ashwagandha : interaction with Anti-anxiety medications

Interaction type:

Interaction rating:
Ashwagandha may effect a chemical in the brain called GABA, which may alter the effects of these medications and possibly the dose needed for treatment. Use with caution. (1)
These drugs include alprazolam, diazepam, lorazepam, clorazepate dipotassium, chlordiazepoxide, oxazepam, buspirone, doxepin, hydroxyzine, meprobamate


  1. Sudhir S, et al. Pharmacological Studies on Leaves of Withania somnifera. Planta Med. Feb1986;1:61-63.