Turmeric and Glibenclamide
Interaction type:
Interactions
Interaction rating:
Potential/Theoretical
Clinical studies have reported that turmeric has effects in reducing Fasting Blood Glucose Level (FBGL) and may alter the effects of these medications and possibly the dose needed for treatment. Use with caution. These results are applicable to glibenclamide. (1)(2)
Turmeric extract was found to be effective in reducing FBGL by 26.5% (from 192.76 to 141.71 mg/dl) and HbA1C levels by 22.3% (from 10.41 to 8.09) in type-2 diabetes mellitus patients who received 200 mg turmeric extract with 5 mg glibenclamide for 14 weeks. (1)(2)
Turmeric and Glimepiride
Interaction type:
Synergistic
Interaction rating:
Potential/Theoretical
Laboratory studies found co-administration of curcumin and glimepiride resulted in a 57.5% reduction in blood glucose levels after 28 days compared to 51.2% with glimepiride alone and 46.8% with curcumin alone in Streptozotocin (STZ) -induced diabetic rats. This suggests that curcumin may be beneficial as an adjuvant to glimepiride in diabetic patients, but further studies are needed to establish their benefits in synergistic combination. (1)(2)
References
1.Thikekar AK, Thomas AB, Chitlange SS. Herb‐drug interactions in diabetes mellitus: A review based on pre‐clinical and clinical data. Phytotherapy Research. 2021 Sep;35(9):4763-81.
2.Ashraf R, Khan RA, Ashraf I. Garlic (Allium sativum) supplementation with standard antidiabetic agent provides better diabetic control in type 2 diabetes patients. Pak J Pharm Sci. 2011;24(4):565–70.
