Healthy Ageing Therapies

Author

Yung-Hsien Chang

Proceeding

Traditional & Complementary Medicine Exhibition 2007 (TCME 2007), Putra World Trade Centre (PWTC), Kuala Lumpur, Malaysia.

Date

17/7/2007

Keyword

Data not available

Abstract

There is more and more stress in the modern society which is competitive between people. Psychological problems like anxiety, emotional imbalance and even psychosis can be attributed to pressure.  Although there are sedative and anti-anxiety drugs to relieve these symptoms to some extent, long-term usage can cause side effect, which include fatigue, lethargy, dullness and memory loss.  Even diseases like Alzheimer’s disease would emerge out earlier than the expected age. Presently the number of drugs enhancing memory is still rare. We apply acupuncture as intervention in this experiment to see whether it works in learning and memory. Our preliminary results indicated that acupuncture at Pai-Hui before or immediately after the training trial could significantly attenuate SCOP-induced impairment in rats. The effects were better than those treated before the light-room retention trial. Interestingly, the identical procedure could also significantly attenuate the CXM-induced impairment, but not those treated before the retention trial. The correction effect of acupuncture on CXM-induced impairment was equivalent to that of piracetam treatment. Acupunctures at Pai-Hui 15, 30 or 60 min before the training trial could be all effective to attenuate CXM-induced impairment, and its efficacy paralleled acupuncture duration. Furthermore, we demonstrated the mechanism of the attenuating effects of acupuncture at Pai-Hui on CXM-induced memory consolidation deficits by combined with SCOP or p-chloroamphetamine (PCA). The attenuating effects of acupuncture at Pai-Hui was significantly antagonized by PCA but not SCOP. These results suggest acupuncture at Pai-Hui might mainly affect the memory storage process and had preventive and immediate therapeutic effects on the CXM-induced impairment and its efficacy paralleled acupuncture duration. The preventive effect of acupuncture at Pai-Hui on CXM-induced impairment is significantly reduced by serotonergic 5-HT releaser. However, the detailed mechanism of acupuncture on memory function and the differential mechanism of acupuncture on memory function an analgesia must be further investigated. In this experiment, the acupuncture mechanism of enhancing learning and memory could be directly correlated to central cholinergic system or indirectly correlated to serotonergic system. Delayed treatment of acupuncture in our experiment merely increases the activity of cholinergic system that antagonize the effect of Scopolamine.  Therefore, we suggest acupuncture could be applied as a clinical intervention for learning & memory disturbance.