Evaluation, Preparation and Clinical Studies of A Herbal Drug  From Oak and Melissa in The Treatment of Recurrent Aphthous Ulcer

Author

Falamarzian M, Moattar H, Moattar F and Jahanshahi Gh

Proceeding

Traditional & Complementary Medicine Exhibition 2007 (TCME 2007), Putra World Trade Centre (PWTC), Kuala Lumpur, Malaysia

Date

17/7/2007

Keyword

Herbal – therapy, Mouth Diseases therapy, Aphthous ulcer, Oak, Melissa.

Abstract

In spite of popularity of Recurrent Aphtous (RAS) and unusual severity of discomfort, there isn’t any complete resolution method for it. So any attempt of developing a remedy is valuable. Major objective in this study is evaluation the efficacy of an herbal drug in controlling of RAS. A double  -bind clinical trial was designed which include 860 patients with RAS and without any systemic background as case who received drug (Oak & Melissa) and another 190 patients with RAS who received placebo (purslane ) .Convenience sampling method and Chi – square & T – test were applied  for analyzing of data. 86.6% of cases showed improvement of ulcer in the first day comparing with no patient of controls in the same periods. Overall improvement in case group was 1.2 ± 0.584 days and in controls was 3.8± 1.437 days. (P value < 0.001) . Complete resolution in case obtains after 3.53 ± 1.664 days and in control after 6.84 ± 0.688 days (P value < 0.001). We couldn't find any statistical difference between case and control about recurrence rate after 3 months follow – up. In this study applying an herbal drug contained Oak fruit and Melissa leaves extract in controlling of RAS was successfully more affordable than placebo. It seems the tannin contains of the both herbs and the flavonoids of Melissa are the main active constituents for the successfully effect of the drug.