Origanum vulgar Inhaler in the Treatment of Chronic Rhinosinositis, a Double Blind Placebo Controlled Randomized Clinical Trial

Author

Madani SA, Azadbakht M, Kosaryan M, Khalilian AR and Rabie K.

Proceeding

Traditional & Complementary Medicine Exhibition 2007 (TCME 2007), Putra World Trade Centre (PWTC), Kuala Lumpur, Malaysia

Date

17/7/2007

Keyword

chronic rhinosinusitis, Origanum vulgar, inhaler

Abstract

Symptoms of chronic rhinisinositis (CRS) are cumbersome and refractory to most systemic medications and even after surgical intervention the recurrence of symptoms are frequent. In order to study the beneficial effect ofOriganum vulgarinhaler in releasing the symptoms,this study was conducted in Boo Ali Sina Hospital Sari, Iran. The study was a randomized double blind placebo controlled clinical trial from April to December 2005. The diagnosis of CRS was made by an ENT specialist upon clinical and CT scans findings and or signs during Functional Endoscopy sinuses surgery (FESS). Patients younger than 15 years old, history of allergic eye disease and symptoms of infections were excluded. Patients, were randomized in case and control groups (32 each) according to age, sex and disease chronicity. After verbal explanation of the trial an informed consent form was signed by each patient.The study was approved by the medical ethics committee of Mazandaran University of Medical Sciences, Iran.O. vulgarwas gathered from local mountains (Kojor area, Nour, Mazandaran, Iran), and identi¿ed by an experience botanist. The aerial organs of the herb were dried, macerated follwed by 75% hydroalcoholic extraction and standardized by Emerson  method. The active ingredient and placebo in same bottles were administered to the patients and they were asked to add 5 ml of the liquid to boiling water and inhale it for 15 minutes, three times a day for two weeks. A telephone contact was made to the patients,to increase the compliance to treatment. A questionnaire was ¿lled for each patient before and after the intervention by a doctor blind to groups. Chi square was used for comparing the differences in symptoms and P< 0.05 was considered statistically significant. Sixty four patients were recruited and allocated equally in case and control grups matched for qge,sex and duration of symptoms. 15.6 and 25 percent of cases and controls had history of sinuses surgery. All symptoms including  headache,nasal congestion, sinus pain ,post nasal discharge, eye pain and purulence in nasal cavity were significantly reduced after the intervention except hyposmia and nasal discharge (p<0.00). No side effect was reported. Inhalation of 75% hydroalcoholic extrac ofO. vulgareffective in releasing most symptoms of CRS