A Paradoxical Finding From Biochemical And Toxicological Evaluations Of Jamu Ratus

Author

Sharom M. Yusof, Harold Baum* and Geoffrey S. Hall.* Biochemistry Department, Faculty of Life Sciences, National University of Malaysia, 43600 UKM Bangi, Malaysia; *Biochemistry Section, Division of Biomolecular Sciences, King's College London, University of London, Campden Hill Road, London W8 7AH, United Kingdom.

Proceeding

Trends in Traditional Medicine Research, Proceedings of the International Conference on the Use of Traditional Medicine & Other Natural Products in Health Care

Date

8/6/1993

Keyword

Jamu Ratus, uncoupling of mitochondrial oxidative phosphorylation, TLC, CHCI3 fraction of EtOH extract (JEC), sedative, 3, 4- dihydroxy phenylacetic acid (DOPAC), homovanilic acid (HVA), DOPA, mouse multi-dimensional test.

Abstract

Cold MeOH extract of Jamu Ratus uncoupled in vitro mitochondrial oxidative phosphorylation without causing hyperthermia in rats. JEC induced catalepsis-like sedation in mice attributable to presence of alkaloid(s) and flavonoid(s). In addition, JEC caused significant increase in serum DOPA and was shown to inhibit DOPA decarboxylase significantly in vitro.