Inhibition Of Platelet Aggregation By Acidic and Neutral Components Of Pinus massoniana Resin

Author

H, T. A. Cheung. S. L. Fu, M. P. Lenguyen, T. Miyase# and M. A. Smal. Department of Pharmacy, University of Sydney, Sydney, NSW 2006, Australia.

Proceeding

Trends in Traditional Medicine Research, Proceedings of the International Conference on the Use of Traditional Medicine & Other Natural Products in Health Care

Date

8/6/1993

Keyword

Pinus massoniana resin, platelet aggregation inhibition, levopimaric acid, longifolene, ß-caryophyllene oxide.

Abstract

The resin of Pinus massoniana Lamb, contains 17 diterpene and trisnorditerpene acids of which 15-hydroxy-7, 13-abietadien-12-on-18-oicacid (14) and8(14)-podocarpene-7,13-dion-18-oicacid (17) are new compounds. Levopimaric acid (2), pimaric acid (1) and two other diterpene acids, as well as longifolene and ß -caryophyllene oxide from the neutral fractions, inhibit in vitro the aggregation of rabbit platelets induced by some or all of the following agonists: platelet activating factor, adenosine 5'-diphosphate and calcium ionophore A23187.