image
Conservation

Compilation of herbal plants (description, geographical distribution, taxonomy, line drawings), biodiversity and herbarium.

Read More
image
Research & Publication

Description of herbal and T&CM research, searchable publication and process from medicinal plant discovery to clinical trial in producing a high-quality registered herbal drug.

Read More
 
Traditional & Complementary Medicine (T&CM)

 

Definition and description of therapies, policy, training and education, research in the practise of (T&CM) and integrated medicine system.           

Read More

 

News Update

Announcement & Advertisement

Forthcoming Events

14th International Conference on Biopharma and Biotherapeutics

From Fri, 25. October 2019 Until Sat, 26. October 2019

World Conference on Pharmaceutical Chemistry and Clinical Research

From Wed, 27. November 2019 Until Thu, 28. November 2019

15th Annual Congress on Pharmacology and Toxicology

From Mon, 2. December 2019 Until Tue, 3. December 2019

3rd International Conference and Exhibition on Pharmaceutical Nanotechnology and Nanomedicine

From Mon, 24. February 2020 Until Tue, 25. February 2020

21st Interntaional Conference and Exhibition on Pharmaceutics & Novel Drug Delivery Systems

From Wed, 11. March 2020 Until Thu, 12. March 2020

A platelet phospholipase inhibitor from the medicinal herb feverfew (Tanacetum parthenium).

Author

Makheja AN, Bailey JM

Date

6/1982

Journal

Prostaglandins Leukot Med

Abstract

Feverfew has been used since antiquity to treat fevers and other inflammatory conditions. Feverfew extracts were found to inhibit ADP, thrombin, or collagen-induced aggregation of human platelets, but significantly, did not affect aggregation induced by arachidonic acid. Synthesis of thromboxane B2 from exogenous 14C-arachidonic acid was also not inhibited. Washed platelets prelabelled with 14C-AA responded normally to thrombin by releasing 14C-TXB2. This was completely blocked by feverfew. A purified platelet phospholipase A2 was inhibited by the material with an I50 of 0.1 antiplatelet units. The pharmacological properties of feverfew may thus be due to an inhibitor of cellular phospholipases, which prevents release of arachidonic acid in response to appropriate physiological stimuli.

Explore Further

Consumer Data

Consumer data including medicinal herbs, dietary supplement monographs, health condition monographs and interactions and depletions.                                    

Read More
Professional Data

Professional data organized into medicinal herbs, dietary supplement monographs, health condition monographs, T&CM herbs, formulas, health conditions, interactions and depletions.

Read More
International Data

We offer International linkages to provide extensive content pertaining to many facets of T&CM as well as Integrated Medicine. Please register for access.    

Read More