Da Zao

Ziziphi Jujubae Fructus, Jujube

Dosage

Decoction: 9-15g.

Chemical Composition

Stepharine; N-nornuciferine; Asimilobine; Zizyphus saponim I, II; Vitamin C, B. (1)

Inorganic Chemicals

Ca, P, Fe.

Precautions

Exercise caution when prescribing Da Zao to patients with excessive dampness, phlegm stagnation, food retention, verminosis, or dental diseases. (2)

Pharmacology

Counteracting leukemia

Experiments show that water-based extract of Da Zao has a significant suppressive effect on the proliferation and colony formation of human leukemia K562 cells. (3)

Effects on the cardiovascular system

Da Zao has a protective effect on experimental cardiac ischemia in rats. It can significantly increase the subjects’ tolerance for oxygen deprivation, counteract various experimental cardiac arrhythmia, suppress platelet aggregation and affect the subjects’ hemodynamics and blood rheology, and enhance rats’ humoral and cell-mediated immune functions. (4)

Counteracting allergic reaction

Da Zao solution can suppress the release of leukotrien D4 by basophilic white blood cells in human peripheral blood. (5)

Effects on the phagocytosis of peritoneal macrophage

In-vivo experiments show that Hong Zao (Da Zao) can increase the phagocytosis of mice’s mononuclear-phagocyte system. (6) , (7)

Counteracting mutation

Experiments show that oral administration of Da Zao decoction can significantly inhibit cyclophosphamide-induced increase in sister chromatid exchange (SCE), indicating that Da Zap has an anti-mutation effect. (8)

Strengthening effect

Fed to mice for 21 consecutive days, Da Zao decoction can significantly increase the subjects’ body weight and swimming capacities. (9)

Anti-aging effects

Experiments show that Da Zao has an inhibitory effect on the activity of monoamine oxidase-B (MAO-B) in mice. (10)

Anti-tumor effects

Administering to mice for 14 consecutive days, Da Zao can inhibit sarcoma-180 (S180) with a 61% inhibition rate. (11)

Anti-inflammatory effects

Extracts of Da Zao leaves can significantly inhibit dimethylbenzene-induced auricular inflammation in mice, egg white-induced toe swelling, and cotton ball-induced granulation tissue proliferation in rats. (12)

References

  1. Ji Xue Ming, et al. Journal of Shizhen Medicinal Material Research. 1997;8(4):373-374.
  2. Li Xue Min, et al. Journal of Shizhen Medicinal Material Research. 1997;8(4):373-374.
  3. Wei Hu Lai, et al. Journal of Gansu College of TCM. 1996;13(3):33-36.
  4. Li Wei Min, et al. China Journal of Ethnic Medicine. 1996;2(1):41-42.
  5. Wu Wei Kang, et al. Foreign Medicine (vol. of TCM). 1984;6(4):54.
  6. Zhang Yan Ying, et al. Journal of Gansu College of TCM. 1995;12(2):50-51.
  7. Zhou Xi Shun. China Journal of Experimental Clinical Immunology. 1992;4(4):35-36.
  8. Song Wei Min, et al. Journal of Pharmacology and Clinical Application of TCM. 1991;7(5):24-25.
  9. Li Xue Min, et al. Journal of Shizhen Medicinal Material Research. 1997;8(4):373-374.
  10. Li Xue Min, et al. Journal of Shizhen Medicinal Material Research. 1997;8(4):373-374.
  11. Li Xue Min, et al. Journal of Shizhen Medicinal Material Research. 1997;8(4):373-374.
  12. Li Xue Min, et al. Journal of Shizhen Medicinal Material Research. 1997;8(4):373-374.