Sang Ji Sheng

Loranthi Ramulus, Loranthus

Dosage

Oral administration, 5:1 concentrated extract: 2-3 grams/day.

Toxicity

LD50 (mice/avicularin/abdominal injection): 1.17g/kg. (1)

Chemical Composition

Quercetin; Avicularin; Triterpenes; Oleanolic acid; Flavonoids; (+)-catechin; Rutin; Isoquercitrin; 7-O-galloyl-(+)-catechin; Quercetin-3-O-(6"-galloyl)-(-D-glucoside; Quercetin-3-O-(6"-galloyl)-(-D-galactoside; Quercetin-3-O-(-D-glucuronide. (2) , (3) , (4)

Precautions

Reported side effects of Sang Ji Sheng include: dizziness, giddiness, anorexia, abdominal distention, and xerostomia, etc. (5)

Pharmacology

Anti-lipid and anti-atherosclerosis effects

Experiments show that Sang Ji Sheng can not only lower lipid content, it can also increase the activity of SOD, help get rid of superoxide free radicals, decrease superoxide lipid, and prevent and treat atherosclerosis. (6) Moreover, research shows that Sang Ji Sheng is conducive to eliminating aortic foam cells in rabbits fed with fat-rich diet, inhibits the proliferation of smooth muscle cells and fibrous tissues, promotes structural recovery in smooth muscle cells, and enhances intracellular lipid metabolism, strengthens the barrier function of aorta endothelial cells. (7)

Effects on enkephalin

Rats with desoxycorticosterone acetate-induced hypertension invariably have elevated levels of methyl enkephalin (MEK) and leucine enkephalin (LEK) in the brain stem and striate body, and a sagged level of MEK in the hypothalamus. As the disease progresses, the blood pressure keeps rising. Even after the initial factors that triggered the hypertension (i.e., DOCA and saline water) are removed, the central enkephalin system remains activated, and the blood pressure remains artificially high. Experiments show that under similar conditions, a treatment with Hu Ji Sheng makes all the difference: the blood pressure and enkephalin level in each region of the brain recovers, MEK and LEK levels in the brain stem and striate body decrease, MEK in the hypothalamus increases, suggesting that Hu Ji Xheng has bi-directional effect of regulating abnormal changes in central enkephalin. (8)

Effects on the heart

Sang Ji Sheng decoction (5.10g/ml) has significant inhibitory effect on chloroform-induced ventricular fibrillation in mice. (9) Bei Ji Sheng is shown to counteract cedilanid-induced arrhythmia, (10) and to repair damages inflicted by experimental myocardiac infarction in dogs. (11)

References

  1. Editorial Committee of Chinese Materia Medica. State Drug Administration of China. Chinese Materia Medica. Shanghai: Science and Techonology Press; 1998.
  2. Chen Ling, et al. Journal of Fujian College of TCM. 1997;7(3):32-33.
  3. Xun Ri Qiang, et al. Journal of Modern Applied Pharmacy. 1993;10(3):35, 36-37.
  4. Li Liang Jing, et al. Journal of Chinese Materia Medica. 1995;26(3):118-121.
  5. Wang Ben Xiang (ed). Modern TCM Pharmacology. Tianjin: Science and Technology Press; 1997.
  6. Hua Yi Li, et al. China Journal of Medicine. 1995;10(1):40-41.
  7. Zhu Guo Ji, et al. Southwest National Defense Journal of Medicine. 1992;2(2):77-78
  8. Zhang Wei Zhong, et al. Journal of Chinese Materia Medica. 1986;17(8):27-28.
  9. Ji Guang Ju, et al. Journal of Shandong College of TCM. 1993;17(1):53-54.
  10. Yue Zhong Wen. Journal of Jilin Medical College. 1981;1(1):15-18.
  11. Meng Fan Hui. Journal of Jilin Medical College. 1982;2(2):12-15.